经合组织/欧洲食品安全局发育神经毒性（DNT）研讨会：用于监管目的的非动物测试方法的使用。 - Suppr

OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes.

作者信息

Fritsche Ellen, Crofton Kevin M, Hernandez Antonio F, Hougaard Bennekou Susanne, Leist Marcel, Bal-Price Anna, Reaves Elissa, Wilks Martin F, Terron Andrea, Solecki Roland, Sachana Magdalini, Gourmelon Anne

机构信息

IUF - Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany.

Heinrich-Heine-University, Duesseldorf, Germany.

出版信息

ALTEX. 2017;34(2):311-315. doi: 10.14573/altex.1701171.

DOI:10.14573/altex.1701171

PMID:28407175

Abstract

摘要

相似文献

OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes.经合组织/欧洲食品安全局发育神经毒性（DNT）研讨会：用于监管目的的非动物测试方法的使用。

ALTEX. 2017;34(2):311-315. doi: 10.14573/altex.1701171.

International Regulatory and Scientific Effort for Improved Developmental Neurotoxicity Testing.国际监管和科学努力以改善发育神经毒性测试。

Toxicol Sci. 2019 Jan 1;167(1):45-57. doi: 10.1093/toxsci/kfy211.

International STakeholder NETwork (ISTNET) for creating a developmental neurotoxicity testing (DNT) roadmap for regulatory purposes.国际利益相关者网络（ISTNET），旨在为监管目的制定发育神经毒性测试（DNT）路线图。

ALTEX. 2014;31(2):223-4. doi: 10.14573/altex.1402121.

The potential of mechanistic information organised within the AOP framework to increase regulatory uptake of the developmental neurotoxicity (DNT) in vitro battery of assays.AOP 框架内组织的机制信息在提高体外发育神经毒性 (DNT)检测组合的监管采用方面的潜力。

Reprod Toxicol. 2021 Aug;103:159-170. doi: 10.1016/j.reprotox.2021.06.006. Epub 2021 Jun 17.

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation.推进发育神经毒性科学（DNT）：为更好的安全性评估进行测试。

ALTEX. 2012;29(2):202-15. doi: 10.14573/altex.2012.2.202.

Meeting report: alternatives for developmental neurotoxicity testing.会议报告：发育神经毒性测试的替代方法

Environ Health Perspect. 2007 May;115(5):764-8. doi: 10.1289/ehp.9841. Epub 2007 Jan 29.

Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals.发育神经毒性测试：用于筛选和优先化化学品的替代方法开发的建议。

ALTEX. 2011;28(1):9-15.

Integrated Approaches to Testing and Assessment.综合测试与评估方法。

Basic Clin Pharmacol Toxicol. 2018 Sep;123 Suppl 5:51-55. doi: 10.1111/bcpt.13018. Epub 2018 May 24.

Towards a regulatory use of alternative developmental neurotoxicity testing (DNT).迈向监管性替代发育神经毒性测试（DNT）的应用。

Toxicol Appl Pharmacol. 2018 Sep 1;354:19-23. doi: 10.1016/j.taap.2018.02.002. Epub 2018 Feb 14.

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.关于为监管目的开展发育神经毒性（DNT）测试，需要创新、转型和实施的共识声明。

Toxicol Appl Pharmacol. 2018 Sep 1;354:3-6. doi: 10.1016/j.taap.2018.02.004. Epub 2018 Feb 12.

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Neural organoids incorporating microglia to assess neuroinflammation and toxicities induced by known developmental neurotoxins.包含小胶质细胞的神经类器官，用于评估已知发育性神经毒素诱导的神经炎症和毒性。

Curr Res Toxicol. 2025 Aug 4;9:100252. doi: 10.1016/j.crtox.2025.100252. eCollection 2025.

In vitro and computational approaches to predict developmental toxicity: Integrating PBPK models with cell-based assays.预测发育毒性的体外和计算方法：将生理药代动力学（PBPK）模型与基于细胞的试验相结合。

Toxicol Appl Pharmacol. 2025 Sep;502:117435. doi: 10.1016/j.taap.2025.117435. Epub 2025 Jun 4.

Stem cell-based approaches for developmental neurotoxicity testing.基于干细胞的发育神经毒性测试方法。

Front Toxicol. 2024 Aug 22;6:1402630. doi: 10.3389/ftox.2024.1402630. eCollection 2024.

Tailoring epilepsy treatment: personalized micro-physiological systems illuminate individual drug responses.定制癫痫治疗方案：个性化微生理系统揭示个体药物反应。

Ann Med Surg (Lond). 2024 Apr 16;86(6):3557-3567. doi: 10.1097/MS9.0000000000002078. eCollection 2024 Jun.

How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity.在替代性全生物体模型中，神经行为和大脑发育如何有助于预测发育性神经毒性。

Neurotoxicology. 2024 May;102:48-57. doi: 10.1016/j.neuro.2024.03.005. Epub 2024 Mar 28.

Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing.新型方法在发育和成年神经毒性测试中的最新进展和当前挑战。

Arch Toxicol. 2024 May;98(5):1271-1295. doi: 10.1007/s00204-024-03703-8. Epub 2024 Mar 13.

Development of an In Vitro Assessment Method for Chemotherapy-Induced Peripheral Neuropathy (CIPN) by Integrating a Microphysiological System (MPS) with Morphological Deep Learning of Soma and Axonal Images.通过将微生理系统（MPS）与体细胞和轴突图像的形态深度学习相结合，开发一种用于化疗诱导的周围神经病变（CIPN）的体外评估方法。

Toxics. 2023 Oct 10;11(10):848. doi: 10.3390/toxics11100848.

Assessment of neurotransmitter release in human iPSC-derived neuronal/glial cells: a missing in vitro assay for regulatory developmental neurotoxicity testing.人诱导多能干细胞源性神经元/神经胶质细胞中神经递质释放的评估：用于监管性发育神经毒性测试的体外检测方法的一项缺失。

Reprod Toxicol. 2023 Apr;117:108358. doi: 10.1016/j.reprotox.2023.108358. Epub 2023 Mar 1.

Use of new approach methodologies (NAMs) to meet regulatory requirements for the assessment of industrial chemicals and pesticides for effects on human health.使用新方法学（NAMs）来满足对工业化学品和农药进行人体健康影响评估的监管要求。

Front Toxicol. 2022 Sep 1;4:964553. doi: 10.3389/ftox.2022.964553. eCollection 2022.

An expert-driven literature review of "negative" chemicals for developmental neurotoxicity (DNT) in vitro assay evaluation.一项由专家主导的关于用于发育神经毒性（DNT）体外试验评估的“阴性”化学物质的文献综述。

Neurotoxicol Teratol. 2022 Sep-Oct;93:107117. doi: 10.1016/j.ntt.2022.107117. Epub 2022 Jul 29.

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OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes.

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