Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.
Angew Chem Int Ed Engl. 2017 May 8;56(20):5546-5550. doi: 10.1002/anie.201701978. Epub 2017 Apr 13.
Constructing polymeric toroids with a uniform, tunable size is challenging. Reported herein is the formation of uniform toroids from poly(γ-benzyl-l-glutamate)-graft-poly(ethylene glycol) (PBLG-g-PEG) graft copolymers by a two-step self-assembly process. In the first step, uniform rodlike micelles are prepared by dialyzing the polymer dissolved in tetrahydrofuran (THF)/N,N'-dimethylformamide (DMF) against water. With the addition of THF in the second step, the rodlike micelles curve and then close end-to-end to form uniform toroids, which resemble a cyclization reaction.
构建具有均匀、可调尺寸的聚合环体具有挑战性。本文报道了通过两步自组装过程，从聚（γ-苄基-L-谷氨酸）-接枝-聚（乙二醇）（PBLG-g-PEG）接枝共聚物形成均匀环体。在第一步中，将聚合物溶解在四氢呋喃（THF）/N，N'-二甲基甲酰胺（DMF）中，然后通过透析在水中制备均匀的棒状胶束。在第二步中，加入 THF 后，棒状胶束弯曲，然后端到端闭合形成均匀的环体，类似于环化反应。
