Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo, Chikusa, Nagoya, 464-8602, Japan.
Department of Chemistry, Queen's University, Chernoff Hall, Kingston, Ontario, Canada.
Angew Chem Int Ed Engl. 2017 May 22;56(22):6198-6202. doi: 10.1002/anie.201701605. Epub 2017 Apr 13.
NHC-Au complexes were used to prepare stable, water-soluble, NHC-protected gold nanoparticles. The water-soluble, charged nature of the nanoparticles permitted analysis by polyacrylamide gel electrophoresis (PAGE), which showed that the nanoparticles were highly monodisperse, with tunable core diameters between 2.0 and 3.3 nm depending on the synthesis conditions. Temporal, thermal, and chemical stability of the nanoparticles were determined to be high. Treatment with thiols caused etching of the particles after 24 h; however larger plasmonic particles showed greater resistance to thiol treatment. These water-soluble, bio-compatible nanoparticles are promising candidates for use in photoacoustic imaging, with even the smallest nanoparticles giving reliable photoacoustic signals.
NHC-Au 配合物被用于制备稳定的、水溶性的、NHC 保护的金纳米粒子。纳米粒子的水溶性和带电性质允许通过聚丙烯酰胺凝胶电泳 (PAGE) 进行分析，结果表明纳米粒子具有高度的单分散性，根据合成条件可以调节核直径在 2.0 到 3.3nm 之间。纳米粒子的时间、热和化学稳定性都很高。巯基处理 24 小时后会导致粒子的蚀刻；然而较大的等离子体纳米粒子对巯基处理表现出更强的抵抗力。这些水溶性、生物相容性的纳米粒子是光声成像的有前途的候选物，即使是最小的纳米粒子也能给出可靠的光声信号。
