肠道微生物群：将空间组织与功能联系起来
The Gut Microbiome: Connecting Spatial Organization to Function.
作者信息
Tropini Carolina, Earle Kristen A, Huang Kerwyn Casey, Sonnenburg Justin L
机构信息
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
出版信息
Cell Host Microbe. 2017 Apr 12;21(4):433-442. doi: 10.1016/j.chom.2017.03.010.
The first rudimentary evidence that the human body harbors a microbiota hinted at the complexity of host-associated microbial ecosystems. Now, almost 400 years later, a renaissance in the study of microbiota spatial organization, driven by coincident revolutions in imaging and sequencing technologies, is revealing functional relationships between biogeography and health, particularly in the vertebrate gut. In this Review, we present our current understanding of principles governing the localization of intestinal bacteria, and spatial relationships between bacteria and their hosts. We further discuss important emerging directions that will enable progressing from the inherently descriptive nature of localization and -omics technologies to provide functional, quantitative, and mechanistic insight into this complex ecosystem.
人体中存在微生物群的首个初步证据暗示了宿主相关微生物生态系统的复杂性。如今，在成像和测序技术同时发生的变革推动下，微生物群空间组织研究迎来复兴，揭示了生物地理学与健康之间的功能关系，尤其是在脊椎动物肠道中。在这篇综述中，我们阐述了目前对肠道细菌定位规律以及细菌与其宿主之间空间关系的理解。我们还将进一步讨论重要的新兴方向，这些方向将使我们从定位和组学技术固有的描述性本质中取得进展，从而对这个复杂的生态系统提供功能性、定量性和机制性的见解。
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