结肠癌中LRP1B的下调促进了癌细胞的生长和迁移。
Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells.
作者信息
Wang Zhiqiang, Sun Peng, Gao Chun, Chen Ji, Li Jun, Chen Zhonghao, Xu Ming, Shao Jun, Zhang Yunpeng, Xie Jiang
机构信息
Department of General of Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xian Xia Road, Shanghai, PR China.
Department of General of Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xian Xia Road, Shanghai, PR China.
出版信息
Exp Cell Res. 2017 Aug 1;357(1):1-8. doi: 10.1016/j.yexcr.2017.04.010. Epub 2017 Apr 11.
Aberrant activation of beta-catenin/TCF signaling is one of the hallmarks of colon cancer. It is of great interest to study the mechanism for the regulation of beta-catenin/TCF signaling. In this study, it was found that LRP1B was down-regulated in colon cancer tissues and inhibited the growth, migration and metastasis of colon cancer cells. The molecular mechanism study revealed that LRP1B interacted with DVL2, inhibited the interaction between DVL2 and Axin, and negatively regulated beta-catenin/TCF signaling. Taken together, our study demonstrated the suppressive roles of LRP1B in the progression of colon cancer, implicating that restoring the function of LRP1B would be a promising strategy for the treatment of colon cancer.
β-连环蛋白/TCF信号通路的异常激活是结肠癌的标志之一。研究β-连环蛋白/TCF信号通路的调控机制具有重要意义。在本研究中，发现LRP1B在结肠癌组织中表达下调，并抑制结肠癌细胞的生长、迁移和转移。分子机制研究表明，LRP1B与DVL2相互作用，抑制DVL2与Axin之间的相互作用，并负向调节β-连环蛋白/TCF信号通路。综上所述，我们的研究证明了LRP1B在结肠癌进展中的抑制作用，这意味着恢复LRP1B的功能可能是治疗结肠癌的一种有前景的策略。
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