Liu Lei, Wu Jinsheng, Wang Shaochuang, Luo Xiaoling, Du Yemu, Huang Dongfang, Gu Dianhua, Zhang Feng
Department of Hepatobiliary & Pancreatic Surgery, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, Jiangsu Province 223300, People's Republic of China.
Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, Jiangsu Province 223300, People's Republic of China.
Exp Cell Res. 2017 Sep 15;358(2):209-216. doi: 10.1016/j.yexcr.2017.06.014. Epub 2017 Jun 23.
Over-activation of beta-catenin/TCF signaling has been frequently observed in hepatocellular carcinoma (HCC). Better understanding the molecular mechanism for the aberrant activation of beta-catenin/TCF signaling would provide novel insights into the treatment of this malignancy. In this study, we have shown that the expression of PKMYT1 was up-regulated in HCC. PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition (EMT) of HCC cells. Mechanically, PKMTY1 activated the beta-catenin/TCF signaling by binding and inactivating GSK3beta. Taken together, our study demonstrated the oncogenic activity of PKMYT1 in the progression of HCC and suggested that PKMYT1 might be a therapeutic target.
β-连环蛋白/TCF信号的过度激活在肝细胞癌（HCC）中经常被观察到。更好地理解β-连环蛋白/TCF信号异常激活的分子机制将为这种恶性肿瘤的治疗提供新的见解。在本研究中，我们已经表明PKMYT1的表达在肝癌中上调。PKMYT1正向调节肝癌细胞的生长、迁移、集落形成、转移和上皮间质转化（EMT）。从机制上讲，PKMTY1通过结合并使GSK3β失活来激活β-连环蛋白/TCF信号。综上所述，我们的研究证明了PKMYT1在肝癌进展中的致癌活性，并表明PKMYT1可能是一个治疗靶点。
