Teixeira Mendes Larissa Sena, Peters Natalie, Attygalle Ayoma D, Wotherspoon Andrew
Histopathology Department, The Royal Marsden Hospital, London, UK.
J Clin Pathol. 2017 Oct;70(10):899-902. doi: 10.1136/jclinpath-2017-204364. Epub 2017 Apr 13.
The recent publication reviewing the updated WHO classification commented on the presence of cyclin D1-positive cells in the proliferation centres (PC) of small lymphocytic lymphoma/chronic lymphocytic leukaemia (SLL/CLL). The figure quoted was 30%, which appeared higher than our experience. To assess cyclin D1 expression in PC of SLL/CLL cases, we performed a review of SLL/CLL cases diagnosed at the Royal Marsden Hospital between 1996 and 2009. Of 105 SLL/CLL cases, 16.2% showed expression of cyclin D1 in PC with none carrying the translocation t(11;14)(q13;q32). Our study and a review of the published literature suggest that this phenomenon occurs with a significantly lower prevalence than that described in the recent review of the updated WHO classification. We confirm that cyclin D1 expression is confined to PC with the typical small lymphocytes being negative. This finding is apparently unrelated to the translocation involving and genes.
最近一篇回顾世界卫生组织（WHO）更新分类的文章提到，在小淋巴细胞淋巴瘤/慢性淋巴细胞白血病（SLL/CLL）的增殖中心（PC）存在细胞周期蛋白D1阳性细胞。文中引用的数据为30%，这一比例似乎高于我们的经验值。为评估SLL/CLL病例PC中细胞周期蛋白D1的表达情况，我们对1996年至2009年在皇家马斯登医院诊断的SLL/CLL病例进行了回顾性研究。在105例SLL/CLL病例中，16.2%的病例PC中显示细胞周期蛋白D1表达，且无一例携带t(11;14)(q13;q32)易位。我们的研究以及对已发表文献的回顾表明，这一现象的发生率明显低于最近WHO更新分类回顾中所描述的情况。我们证实细胞周期蛋白D1的表达仅限于PC，典型的小淋巴细胞呈阴性。这一发现显然与涉及 和 基因的易位无关。 （注：原文中“involving and genes”部分两个“ ”处信息缺失）
