超越自噬：Parkin 功能的多样性和复杂性。
Beyond Mitophagy: The Diversity and Complexity of Parkin Function.
机构信息
From the Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla (S.E.S., A.B.G.); and Departments of Medicine and Cell Biology, Wilf Family Cardiovascular Research Institute, Diabetes Research Center, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY (R.N.K.).
出版信息
Circ Res. 2017 Apr 14;120(8):1234-1236. doi: 10.1161/CIRCRESAHA.116.310179.
Abstract
Parkin is an E3 ubiquitin ligase that mediates mitochondrial autophagy, or mitophagy, in multiple cell types. While discovered in the context of Parkinson’s disease, Parkin is also an important regulator of mitophagy in the heart. In addition, while most current work is focused on the role of Parkin in mitophagy, accumulating evidence suggests that Parkin also impacts cellular physiology and function through additional processes. This Viewpoint discusses current controversies regarding the functional role of Parkin-mediated mitophagy and emerging evidence that Parkin regulates several additional pathways.
摘要
Parkin 是一种 E3 泛素连接酶，可介导多种细胞类型中的线粒体自噬或 mitophagy。虽然 Parkin 是在帕金森病的背景下被发现的，但它也是心脏中线粒体自噬的重要调节因子。此外，虽然目前大多数研究都集中在 Parkin 在 mitophagy 中的作用，但越来越多的证据表明，Parkin 还通过其他过程影响细胞的生理和功能。本观点讨论了目前关于 Parkin 介导的 mitophagy 的功能作用的争议，以及 Parkin 调节几个其他途径的新证据。
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