T细胞急性淋巴细胞白血病的全基因组非编码序列分析确定了致癌基因增强子突变。
Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations.
作者信息
Hu Shaoyan, Qian Maoxiang, Zhang Hui, Guo Yu, Yang Jin, Zhao Xujie, He Hailong, Lu Jun, Pan Jian, Chang Meimei, Du Guoqing, Lin Ting-Nien, Kham Shirley Kow-Yin, Quah Thuan Chong, Ariffin Hany, Tan Ah-Moy, Cheng Yong, Li Chunliang, Yeoh Allen Eng-Juh, Pui Ching-Hon, Skanderup Anders Jacobsen, Yang Jun J
机构信息
Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
出版信息
Blood. 2017 Jun 15;129(24):3264-3268. doi: 10.1182/blood-2017-03-771162. Epub 2017 Apr 13.
Abstract
There is an Inside Commentary on this article in this issue.
摘要
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本文引用的文献
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Activation of the oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.在T细胞急性淋巴细胞白血病中，通过体细胞获得的新形态启动子激活致癌基因。
Blood. 2017 Jun 15;129(24):3221-3226. doi: 10.1182/blood-2016-09-742148. Epub 2017 Mar 7.
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Small genomic insertions form enhancers that misregulate oncogenes.小的基因组插入形成增强子，导致致癌基因失调。
Nat Commun. 2017 Feb 9;8:14385. doi: 10.1038/ncomms14385.
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The genetics and mechanisms of T cell acute lymphoblastic leukaemia.T 细胞急性淋巴细胞白血病的遗传学和机制。
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