Elbaz-Alon Yael
Department of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, U.S.A.
Biochem Soc Trans. 2017 Apr 15;45(2):477-488. doi: 10.1042/BST20160130.
Membrane contact sites (MCSs) are areas of close apposition between the membranes of two different organelles that enable non-vesicular transfer of ions and lipids. Recent studies reveal that mitochondria maintain contact sites with organelles other than the endoplasmic reticulum such as the vacuole, plasma membrane and peroxisomes. This review focuses on novel findings achieved mainly in yeast regarding tethers, function and regulation of mitochondria-organelle contact sites. The emerging network of MCSs linking virtually all cellular organelles is highly dynamic and integrated with cellular metabolism.
膜接触位点（MCSs）是两个不同细胞器的膜紧密并置的区域，能够实现离子和脂质的非囊泡转运。最近的研究表明，线粒体与内质网以外的细胞器保持接触位点，如液泡、质膜和过氧化物酶体。本综述重点关注主要在酵母中取得的关于线粒体-细胞器接触位点的栓系、功能和调节的新发现。连接几乎所有细胞器的新兴MCSs网络具有高度动态性，并与细胞代谢整合在一起。
