Institut für Zellbiologie, Universität Bayreuth, 95440 Bayreuth, Germany.
Institut für Zellbiologie, Universität Bayreuth, 95440 Bayreuth, Germany.
Trends Cell Biol. 2014 Sep;24(9):537-45. doi: 10.1016/j.tcb.2014.04.004. Epub 2014 Apr 28.
Mitochondria are highly dynamic organelles. During their life cycle they frequently fuse and divide, and damaged mitochondria are removed by autophagic degradation. These processes serve to maintain mitochondrial function and ensure optimal energy supply for the cell. It has recently become clear that this complex mitochondrial behavior is governed to a large extent by interactions with other organelles. In this review, we describe mitochondrial contacts with the endoplasmic reticulum (ER), plasma membrane, and peroxisomes. In particular, we highlight how mitochondrial fission, distribution, inheritance, and turnover are orchestrated by interorganellar contacts in yeast and metazoa. These interactions are pivotal for the integration of the dynamic mitochondrial network into the architecture of eukaryotic cells.
线粒体是高度动态的细胞器。在它们的生命周期中，它们经常融合和分裂，受损的线粒体被自噬降解所清除。这些过程有助于维持线粒体的功能，并确保细胞有最佳的能量供应。最近人们清楚地认识到，这种复杂的线粒体行为在很大程度上受到与其他细胞器相互作用的控制。在这篇综述中，我们描述了线粒体与内质网（ER）、质膜和过氧化物酶体的接触。特别是，我们强调了酵母和后生动物中线粒体分裂、分布、遗传和周转是如何通过细胞器间的接触来协调的。这些相互作用对于将动态的线粒体网络整合到真核细胞的架构中至关重要。
