College of Life and Environmental Sciences, Biosciences, University of Exeter, Exeter, UK.
Institute of Neuroanatomy, Center for Biomedicine and Medical Technology Mannheim, Medical Faculty Manheim, University of Heidelberg, Mannheim, Germany.
J Inherit Metab Dis. 2020 Jan;43(1):71-89. doi: 10.1002/jimd.12083. Epub 2019 Apr 16.
Peroxisomes are multifunctional, dynamic, membrane-bound organelles with important functions in cellular lipid metabolism, rendering them essential for human health and development. Important roles for peroxisomes in signaling and the fine-tuning of cellular processes are emerging, which integrate them in a complex network of interacting cellular compartments. Like many other organelles, peroxisomes communicate through membrane contact sites. For example, peroxisomal growth, positioning, and lipid metabolism involves contacts with the endoplasmic reticulum (ER). Here, we discuss the most recent findings on peroxisome-organelle interactions including peroxisome-ER interplay at membrane contacts sites, and functional interplay with mitochondria, lysosomes, and lipid droplets in mammalian cells. We address tether proteins, metabolic cooperation, and the impact of peroxisome interactions on human health and disease.
过氧化物酶体是多功能的、动态的、膜结合的细胞器，在细胞脂质代谢中具有重要功能，对人类健康和发育至关重要。过氧化物酶体在信号转导和细胞过程的精细调控中发挥着重要作用，这将它们整合到一个相互作用的细胞区室的复杂网络中。与许多其他细胞器一样，过氧化物酶体通过膜接触位点进行通讯。例如，过氧化物酶体的生长、定位和脂质代谢涉及与内质网 (ER) 的接触。在这里，我们讨论了过氧化物酶体-细胞器相互作用的最新发现，包括膜接触位点处的过氧化物酶体-ER 相互作用，以及与哺乳动物细胞中线粒体、溶酶体和脂滴的功能相互作用。我们讨论了连接蛋白、代谢合作，以及过氧化物酶体相互作用对人类健康和疾病的影响。
