Tobaldini Eleonora, Covassin Naima, Calvin Andrew, Singh Prachi, Bukartyk Jan, Wang Shiang, Montano Nicola, Somers Virend K
Department of Internal Medicine, Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Department of Clinical Sciences and Community of Health, University of Milan, Milan, Italy.
Physiol Rep. 2017 Apr;5(7). doi: 10.14814/phy2.13197.
Acute sleep deprivation (SD) alters cardiovascular autonomic control (CAC) and is associated with an increased risk of cardiovascular disorders. However, the effects of partial SD on CAC are unclear. Thus, we aimed to investigate the effects of partial SD on CAC during sleep. We randomized seventeen healthy subjects to a restriction group (RES, = 8, subjects slept two-thirds of normal sleep time based on individual habitual sleep duration for 8 days and 8 nights) or a Control group (CON, = 9, subjects were allowed to sleep their usual sleep time). Attended polysomnographic (PSG) studies were performed every night; a subset of them was selected for the analysis at baseline (day 3-D3), the first night after sleep restriction (day 5-D5), at the end of sleep restriction period (day 11-D11), and at the end of recovery phase (day 14-D14). We extracted electrocardiogram (ECG) and respiration from the PSG and divided into wakefulness (W), nonrapid eye movements (REM) sleep (N2 and N3) and REM sleep. CAC was evaluated by means of linear spectral analysis, nonlinear symbolic analysis and complexity indexes. In both RES and CON groups, sympathetic modulation decreased and parasympathetic modulation increased during N2 and N3 compared to W and REM at D3, D5, D11, D14. Complexity analysis revealed a reduction in complexity during REM compared to NREM sleep in both DEP and CON After 8 days of moderate SD, cardiac autonomic dynamics, characterized by decreased sympathetic, and increased parasympathetic modulation, and higher cardiac complexity during NREM sleep, compared to W and REM, are preserved.
急性睡眠剥夺（SD）会改变心血管自主神经控制（CAC），并与心血管疾病风险增加有关。然而，部分睡眠剥夺对CAC的影响尚不清楚。因此，我们旨在研究睡眠期间部分睡眠剥夺对CAC的影响。我们将17名健康受试者随机分为限制组（RES，n = 8，受试者根据个人习惯睡眠时间在8天8夜内睡正常睡眠时间的三分之二）或对照组（CON，n = 9，受试者被允许按其平常睡眠时间睡眠）。每晚进行多导睡眠图（PSG）研究；在基线（第3天 - D3）、睡眠限制后的第一个晚上（第5天 - D5）、睡眠限制期结束时（第11天 - D11）和恢复阶段结束时（第14天 - D14），从中选取一部分进行分析。我们从PSG中提取心电图（ECG）和呼吸信号，并分为清醒（W）、非快速眼动（REM）睡眠（N2和N3）以及REM睡眠。通过线性谱分析、非线性符号分析和复杂性指标评估CAC。在RES组和CON组中，与D3、D5、D11、D14时的W和REM相比，N2和N3期间交感神经调制降低，副交感神经调制增加。复杂性分析显示，在DEP组和CON组中，与NREM睡眠相比，REM期间的复杂性降低。在适度睡眠剥夺8天后，以交感神经降低、副交感神经调制增加以及与W和REM相比NREM睡眠期间心脏复杂性更高为特征的心脏自主神经动力学得以保留。
