Shi Xiaohan, Jia Yingxian, Xie Xiaochuan, Li Shangwei
Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University.
Genes Genet Syst. 2018 Feb 10;92(4):173-187. doi: 10.1266/ggs.16-00024. Epub 2017 Apr 12.
The associations between interleukin-12 (IL-12) gene polymorphisms and cancer risk have been discussed extensively, with controversial results. Therefore, we conducted the present meta-analysis to better assess the potential roles of IL-12 gene variation in cancer occurrence. Eligible articles were found via PubMed, Medline, EMBASE, Google Scholar and CNKI. Odds ratios and 95% confidence intervals were used to evaluate the associations between IL-12 gene polymorphisms and cancer risk. Thirty-one studies with 10,749 cancer patients and 11,921 healthy subjects were included in the analyses. The overall results showed that cancer risk was increased by IL-12A rs568408 (GG versus GA + AA: P = 0.004; G versus A: P = 0.005) and IL-12B rs3212227 (AA versus AC + CC: P = 0.004; CC versus AA + AC: P = 0.03; A versus C: P = 0.007) polymorphisms. Further subgroup analyses for IL-12A rs568408 and IL-12B rs3212227 revealed that the positive results could be impacted by the ethnicity of the population, cancer type and/or genotyping methods. However, we failed to detect any significant associations between the IL-12A rs2243115 polymorphism and cancer risk in either the overall or the subgroup analyses. The current study suggests that certain IL-12 gene polymorphisms serve as biological markers of cancer susceptibility.
白细胞介素-12（IL-12）基因多态性与癌症风险之间的关联已被广泛讨论，但结果存在争议。因此，我们进行了本荟萃分析，以更好地评估IL-12基因变异在癌症发生中的潜在作用。通过PubMed、Medline、EMBASE、谷歌学术和中国知网检索符合条件的文章。采用比值比和95%置信区间来评估IL-12基因多态性与癌症风险之间的关联。分析纳入了31项研究，共10749例癌症患者和11921例健康受试者。总体结果显示，IL-12A rs568408（GG与GA + AA相比：P = 0.004；G与A相比：P = 0.005）和IL-12B rs3212227（AA与AC + CC相比：P = 0.004；CC与AA + AC相比：P = 0.03；A与C相比：P = 0.007）多态性会增加癌症风险。对IL-12A rs568408和IL-12B rs3212227的进一步亚组分析表明，阳性结果可能受到人群种族、癌症类型和/或基因分型方法的影响。然而，在总体分析或亚组分析中，我们均未发现IL-12A rs2243115多态性与癌症风险之间存在任何显著关联。当前研究表明，某些IL-12基因多态性可作为癌症易感性的生物学标志物。
