肝细胞癌风险与rs3212227和rs568408基因多态性之间的关联：一项系统评价和荟萃分析。
Associations between hepatocellular carcinoma risk and rs3212227 and rs568408 polymorphisms: a systematic review and meta-analysis.
作者信息
Kong Cunqing, Chen Miao, Fan Xiaohui, Chen Xingcai
机构信息
Department of Microbiology, The School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Department of Radiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China.
出版信息
J Int Med Res. 2020 Aug;48(8):300060520943420. doi: 10.1177/0300060520943420.
BACKGROUND
Interleukin-12 (IL-12) is considered to be a risk factor for cancer; however, its role in hepatocellular carcinoma (HCC) remains unknown. This study aimed to explore the impacts of the IL-12 rs3212227 and rs568408 gene polymorphisms on HCC.
METHODS
We searched PubMed, Embase, Web of Science, and Chinese Knowledge Infrastructure databases for studies on the associations between HCC and IL-12 rs568408 and rs3212227 polymorphisms published prior to 1 May 2020. The effects of the polymorphisms on HCC susceptibility were presented as odds ratios (ORs) and associated 95% confidence intervals.
RESULTS
Seven studies were ultimately included, including 2375 cases and 3445 controls. The rs3212227 polymorphism was significantly associated with the risk of HCC in both the dominant model (CC+AC vs. AA, OR=1.22) and the allele model (C vs. A, OR=1.12). Combined analysis of rs568408 yielded a significant relative risk for HCC in the dominant (AA+AG vs. GG, OR=1.13), recessive (AA vs. AG+GG, OR=1.72), allele (A vs. G, OR=1.29), heterozygote (AG vs. GG, OR=1.27), and homozygote models (AA vs. GG, OR 1.17).
CONCLUSION
The IL-12 rs3212227 and rs568408 gene polymorphisms are associated with an increased risk of HCC.
背景
白细胞介素-12（IL-12）被认为是癌症的一个风险因素；然而，其在肝细胞癌（HCC）中的作用尚不清楚。本研究旨在探讨IL-12 rs3212227和rs568408基因多态性对HCC的影响。
方法
我们检索了PubMed、Embase、Web of Science和中国知网数据库，以查找2020年5月1日前发表的关于HCC与IL-12 rs568408和rs3212227多态性之间关联的研究。多态性对HCC易感性的影响以比值比（OR）和相关的95%置信区间表示。
结果
最终纳入7项研究，包括2375例病例和3445例对照。rs3212227多态性在显性模型（CC+AC vs. AA，OR=1.22）和等位基因模型（C vs. A，OR=1.12）中均与HCC风险显著相关。rs568408的合并分析在显性（AA+AG vs. GG，OR=1.13）、隐性（AA vs. AG+GG，OR=1.72）、等位基因（A vs. G，OR=1.29）、杂合子（AG vs. GG，OR=1.27）和纯合子模型（AA vs. GG，OR 1.17）中均产生了HCC的显著相对风险。
结论
IL-12 rs3212227和rs568408基因多态性与HCC风险增加相关。
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