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白细胞介素-12基因多态性在癌症发病风险中的作用：一项荟萃分析。

Role of interleukin-12 gene polymorphisms in the onset risk of cancer: a meta-analysis.

作者信息

Zheng Yi, Wang Meng, Tian Tian, Liu Kang, Liu Xinghan, Zhai Yajing, Lin Shuai, Yang Pengtao, Li Shanli, Dai Zhijun, Lu Jun

机构信息

Clinical Research Center, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.

Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, China.

出版信息

Oncotarget. 2017 May 2;8(18):29795-29807. doi: 10.18632/oncotarget.16080.

DOI:10.18632/oncotarget.16080
PMID:28415696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5444704/
Abstract

Many molecular epidemiologic studies have explored the possible links between interleukin-12 (IL-12) polymorphisms and various cancers. However, results from these studies remain inconsistent. This meta-analysis is aimed to shed light on the associations between three common loci (rs568408, rs2243115, rs3212227) of IL-12 gene and overall cancer risk. Our meta-analysis finally included 33 studies comprising 10,587 cancer cases and 12,040 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the cancer risk. We observed a significant association between IL-12B rs3212227 and overall cancer risk, especially in hepatocellular carcinoma, nasopharyngeal cancer, and among Asians. IL-12A polymorphisms (rs2243115 and rs568408) were found no influence on overall cancer risk. Nevertheless, stratification analyses demonstrated that rs568408 polymorphism contributed to increasing cancer risk of Caucasians and cervical cancer. And, rs2243115 may enhance the risk of brain tumor. These findings provided evidence that IL-12 polymorphisms may play a potential role in cancer risk.

摘要

许多分子流行病学研究探讨了白细胞介素-12（IL-12）基因多态性与各种癌症之间的可能联系。然而，这些研究的结果仍然不一致。本荟萃分析旨在阐明IL-12基因的三个常见位点（rs568408、rs2243115、rs3212227）与总体癌症风险之间的关联。我们的荟萃分析最终纳入了33项研究，包括10587例癌症病例和12040例无癌对照。比值比（OR）和95%置信区间（CI）用于评估癌症风险。我们观察到IL-12B rs3212227与总体癌症风险之间存在显著关联，尤其是在肝细胞癌、鼻咽癌以及亚洲人群中。发现IL-12A基因多态性（rs2243115和rs568408）对总体癌症风险没有影响。然而，分层分析表明，rs568408多态性会增加白种人和宫颈癌的癌症风险。而且，rs2243115可能会增加患脑肿瘤的风险。这些发现提供了证据，表明IL-12基因多态性可能在癌症风险中发挥潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/dc1559ec13bc/oncotarget-08-29795-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/9976c2c0a71b/oncotarget-08-29795-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/7419d6d2589b/oncotarget-08-29795-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/274fac28a8ce/oncotarget-08-29795-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/3d5aa93d3bcb/oncotarget-08-29795-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/25a5a9216dd1/oncotarget-08-29795-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/dc1559ec13bc/oncotarget-08-29795-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/9976c2c0a71b/oncotarget-08-29795-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/7419d6d2589b/oncotarget-08-29795-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/274fac28a8ce/oncotarget-08-29795-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/3d5aa93d3bcb/oncotarget-08-29795-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/25a5a9216dd1/oncotarget-08-29795-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856b/5444704/dc1559ec13bc/oncotarget-08-29795-g006.jpg

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1
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2
Evaluation of the circulating levels of IL-12 and IL-33 in patients with breast cancer: influences of the tumor stages and cytokine gene polymorphisms.乳腺癌患者循环中白细胞介素-12和白细胞介素-33水平的评估：肿瘤分期和细胞因子基因多态性的影响
Iran J Basic Med Sci. 2015 Dec;18(12):1189-98.
3
Cancer statistics in China, 2015.《中国癌症统计数据 2015》
Front Immunol. 2022 Aug 12;13:948358. doi: 10.3389/fimmu.2022.948358. eCollection 2022.
4
A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma.一项关于 XRCC3 rs861539、MTHFR rs1801133、IL-6 rs1800795、IL-12B rs3212227、TNF-α rs1800629 和 TLR9 rs352140 多态性与宫颈癌易感性关联的荟萃分析。
Asian Pac J Cancer Prev. 2021 Nov 1;22(11):3419-3431. doi: 10.31557/APJCP.2021.22.11.3419.
5
Genetic Influences in Breast Cancer Drug Resistance.乳腺癌耐药中的遗传影响
Breast Cancer (Dove Med Press). 2021 Feb 9;13:59-85. doi: 10.2147/BCTT.S284453. eCollection 2021.
6
Immunology of IL-12: An update on functional activities and implications for disease.白细胞介素-12的免疫学：功能活性及疾病相关性的最新进展
EXCLI J. 2020 Dec 11;19:1563-1589. doi: 10.17179/excli2020-3104. eCollection 2020.
7
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