Martin Sarah, Al Khleifat Ahmad, Al-Chalabi Ammar
Maurice Wohl Clinical Neuroscience Institute, King's College, London, UK.
F1000Res. 2017 Mar 28;6:371. doi: 10.12688/f1000research.10476.1. eCollection 2017.
Amyotrophic lateral sclerosis is a neurodegenerative disease predominantly affecting upper and lower motor neurons, resulting in progressive paralysis and death from respiratory failure within 2 to 3 years. The peak age of onset is 55 to 70 years, with a male predominance. The causes of amyotrophic lateral sclerosis are only partly known, but they include some environmental risk factors as well as several genes that have been identified as harbouring disease-associated variation. Here we review the nature, epidemiology, genetic associations, and environmental exposures associated with amyotrophic lateral sclerosis.
肌萎缩侧索硬化症是一种神经退行性疾病，主要影响上下运动神经元，导致进行性瘫痪，并在2至3年内因呼吸衰竭而死亡。发病的高峰年龄为55至70岁，男性居多。肌萎缩侧索硬化症的病因仅部分为人所知，但包括一些环境风险因素以及几个已被确定存在与疾病相关变异的基因。在此，我们综述与肌萎缩侧索硬化症相关的性质、流行病学、遗传关联和环境暴露情况。
