Janga Kalyana C, Sinha Ankur, Greenberg Sheldon, Sharma Kavita
Department of Nephrology, Maimonides Medical Center, Brooklyn, NY, USA.
Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY, USA.
Case Rep Nephrol. 2017;2017:9460671. doi: 10.1155/2017/9460671. Epub 2017 Mar 20.
A 53-year-old Egyptian female with end stage renal disease, one month after start of hemodialysis via an internal jugular catheter, presented with fever and shortness of breath. She developed desquamating vesiculobullous lesions, widespread on her body. She was in profound septic shock and broad spectrum antibiotics were started with appropriate fluid replenishment. An echocardiogram revealed bulky leaflets of the mitral valve with a highly mobile vegetation about 2.3 cm long attached to the anterior leaflet. CT scan of the chest, abdomen, and pelvis showed bilateral pleural effusions in the chest, with triangular opacities in the lungs suggestive of infarcts. There was splenomegaly with triangular hypodensities consistent with splenic infarcts. Blood cultures repeatedly grew . Despite parenteral antifungal therapy, the patient deteriorated over the course of 5 days. She died due to a subsequent cardiac arrest. Systemic review of literature revealed that the rate of infection varies amongst the various types of accesses, and it is well documented that AV fistulas have a much less rate of infection in comparison to temporary catheters. All dialysis units should strive to make a multidisciplinary effort to have a referral process early on, for access creation, and to avoid catheters associated morbidity.
一名53岁的埃及女性,患有终末期肾病,在通过颈内静脉导管开始血液透析一个月后,出现发热和呼吸急促。她身上出现了脱皮性水疱大疱性病变,遍布全身。她处于严重的感染性休克状态,开始使用广谱抗生素并进行适当的液体补充。超声心动图显示二尖瓣叶增厚,有一个长约2.3厘米、高度活动的赘生物附着在前叶上。胸部、腹部和骨盆的CT扫描显示胸部双侧胸腔积液,肺部有三角形混浊影,提示梗死。有脾肿大,伴有与脾梗死一致的三角形低密度影。血培养多次培养出…… 尽管进行了肠外抗真菌治疗,但患者在5天内病情恶化。她因随后的心脏骤停死亡。对文献的系统回顾显示,不同类型的血管通路感染率各不相同,且有充分记录表明,与临时导管相比,动静脉内瘘的感染率要低得多。所有透析单位都应努力进行多学科协作,尽早建立转诊流程,以建立血管通路,并避免与导管相关的发病率。