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从三叶草根瘤叶杆菌PETP02脂多糖中分离出的脂质A的研究。

Studies on lipid A isolated from Phyllobacterium trifolii PETP02 lipopolysaccharide.

作者信息

Zamlynska Katarzyna, Komaniecka Iwona, Zebracki Kamil, Mazur Andrzej, Sroka-Bartnicka Anna, Choma Adam

机构信息

Department of Genetics and Microbiology, Maria Curie-Sklodowska University, Akademicka 19, 20-033, Lublin, Poland.

Department of General Microbiology, Maria Curie-Sklodowska University, Akademicka 19, 20-033, Lublin, Poland.

出版信息

Antonie Van Leeuwenhoek. 2017 Nov;110(11):1413-1433. doi: 10.1007/s10482-017-0872-0. Epub 2017 Apr 13.

DOI:10.1007/s10482-017-0872-0
PMID:28409238
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5644692/
Abstract

The structure of lipid A from lipopolysaccharide of Phyllobacterium trifolii PETP02, a nitrogen-fixing symbiotic bacterium, was studied. It was found that the lipid A backbone was composed of two 2,3-diamino-2,3-dideoxy-D-glucose (GlcpN3N) residues connected by a β-(1 → 6) glycosidic linkage, substituted by galacturonic acid (GalpA) at position C-1 and partly decorated by a phosphate residue at C-4' of the non-reducing GlcpN3N. Both diaminosugars were symmetrically substituted by 3-hydroxy fatty acids (14:0(3-OH) and 16:0(3-OH)). Ester-linked secondary acyl residues [i.e. 19:0cyc and 28:0(27-OH) or 28:0(27-4:0(3-OMe))] were located in the distal part of lipid A. A high similarity between the lipid A of P. trifolii and Mesorhizobium was observed and discussed from the perspective of the genetic context of both genomes.

摘要

对固氮共生细菌三叶草根瘤菌PETP02脂多糖中脂质A的结构进行了研究。发现脂质A骨架由两个通过β-(1→6)糖苷键连接的2,3-二氨基-2,3-二脱氧-D-葡萄糖（GlcpN3N）残基组成，在C-1位被半乳糖醛酸（GalpA）取代，在非还原端GlcpN3N的C-4'位部分被磷酸残基修饰。两个二氨基糖均被3-羟基脂肪酸（14:0(3-OH)和16:0(3-OH)）对称取代。酯键连接的二级酰基残基[即19:0cyc和28:0(27-OH)或28:0(27-4:0(3-OMe))]位于脂质A的远端部分。从两个基因组的遗传背景角度观察并讨论了三叶草根瘤菌和中生根瘤菌脂质A之间的高度相似性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/5644692/71a24fd4fe07/10482_2017_872_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/5644692/0f4d36d5ea87/10482_2017_872_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/5644692/8d7717862de3/10482_2017_872_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/5644692/c58b8369985b/10482_2017_872_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/5644692/bc39a851d182/10482_2017_872_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/5644692/71a24fd4fe07/10482_2017_872_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/5644692/0f4d36d5ea87/10482_2017_872_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/5644692/8d7717862de3/10482_2017_872_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/5644692/c58b8369985b/10482_2017_872_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/5644692/bc39a851d182/10482_2017_872_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/5644692/71a24fd4fe07/10482_2017_872_Fig5_HTML.jpg

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