De Luca N, Ricciardelli B, Rosiello G, Lembo G, Volpe M, Cuocolo A, Trimarco B
Clinica Medica, Facoltà di Medicina, Università di Napoli, Italy.
Am J Hypertens. 1988 Apr;1(2):181-3. doi: 10.1093/ajh/1.2.181.
In 12 patients with mild or moderate essential hypertension we assessed by 2-D pulsed Doppler flowmetry the influence of a 6-month effective treatment with enalapril or atenolol on peripheral hemodynamics. The patients were studied in control conditions, at the end of the 6-month pharmacologic treatment, and 2 weeks after the withdrawal of the therapy. In spite of a comparable fall in blood pressure, the effects of the two drugs on forearm hemodynamics were quite different. Enalapril induced a fall in vascular resistance and an increase in brachial artery diameter, flow, and compliance, while atenolol failed to modify all these parameters. In the enalapril group the improvement in forearm vascular resistance and brachial artery compliance persisted after the 2-week washout period. This latter observation raises the possibility that enalapril may reverse structural changes in the large arteries.
我们用二维脉冲多普勒血流仪对12例轻、中度原发性高血压患者进行研究，评估依那普利或阿替洛尔6个月有效治疗对外周血流动力学的影响。在对照条件下、6个月药物治疗结束时以及停药2周后对患者进行研究。尽管两种药物使血压下降程度相当，但它们对前臂血流动力学的影响却截然不同。依那普利使血管阻力下降，肱动脉直径、血流量及顺应性增加，而阿替洛尔未能改变所有这些参数。在依那普利组，2周洗脱期后前臂血管阻力及肱动脉顺应性仍持续改善。后一观察结果提示依那普利可能逆转大动脉的结构改变。
