Agaba Patricia A, Meloni Seema T, Sule Halima M, Ocheke Amaka N, Agaba Emmanuel I, Idoko John A, Kanki Phyllis J
1 Department of Family Medicine, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
2 APIN Centre, Jos University Teaching Hospital, Jos, Nigeria.
Int J STD AIDS. 2017 Nov;28(13):1325-1334. doi: 10.1177/0956462417704778. Epub 2017 Apr 14.
We compared the prevalence of menopause symptoms between women living with HIV to their HIV-negative peers and determined predictors of severe menopause symptoms in Jos, Nigeria. This descriptive cross-sectional study included 714 women aged 40-80 years. We compared prevalence and severity of menopause symptoms using the menopause rating scale (MRS). Logistic regression analysis was used to determine the predictors of severe symptoms. Six-hundred and seven (85.0%) were HIV-positive, with a mean duration of infection of 5.6 ± 2.7 years. The mean age of the cohort was 46 ± 5 years. The most prevalent menopause symptoms were hot flushes (67.2%), joint and muscle discomfort (66.2%), physical/mental exhaustion (65.3%), heart discomfort (60.4%), and anxiety (56.4%). The median MRS score was higher for HIV-positive compared to HIV-negative women (p = 0.01). Factors associated with severe menopause symptoms included HIV-positive status (aOR: 3.01, 95% CI: 1.20-7.54) and history of cigarette smoking (aOR: 4.18, 95% CI: 1.31-13.26). Being married (aOR: 0.49, 95% CI: 0.32-0.77), premenopausal (aOR: 0.60, 95% CI: 0.39-0.94), and self-reporting good quality of life (aOR: 0.62. 95% CI: 0.39-0.98) were protective against severe menopause symptoms. We found HIV infection, cigarette smoking, quality of life, and stage of the menopause transition to be associated with severe menopause symptoms. As HIV-positive populations are aging, additional attention should be given to the reproductive health of these women.
我们比较了感染艾滋病毒的女性与其未感染艾滋病毒的同龄人之间更年期症状的患病率，并确定了尼日利亚乔斯地区严重更年期症状的预测因素。这项描述性横断面研究纳入了714名年龄在40至80岁之间的女性。我们使用更年期评分量表（MRS）比较了更年期症状的患病率和严重程度。采用逻辑回归分析来确定严重症状的预测因素。607名（85.0%）为艾滋病毒阳性，平均感染时长为5.6±2.7年。该队列的平均年龄为46±5岁。最常见的更年期症状为潮热（67.2%）、关节和肌肉不适（66.2%）、身心疲惫（65.3%）、心脏不适（60.4%）以及焦虑（56.4%）。艾滋病毒阳性女性的MRS中位数得分高于艾滋病毒阴性女性（p = 0.01）。与严重更年期症状相关的因素包括艾滋病毒阳性状态（调整后比值比：3.01，95%置信区间：1.20 - 7.54）以及吸烟史（调整后比值比：4.18，95%置信区间：1.31 - 13.26）。已婚（调整后比值比：0.49，95%置信区间：0.32 - 0.77）、绝经前（调整后比值比：0.60，95%置信区间：0.39 - 0.94）以及自我报告生活质量良好（调整后比值比：0.62，95%置信区间：0.39 - 0.98）对严重更年期症状具有保护作用。我们发现艾滋病毒感染、吸烟、生活质量以及更年期过渡阶段与严重更年期症状相关。随着艾滋病毒阳性人群的老龄化，应给予这些女性的生殖健康更多关注。
