阿尔茨海默病中神经递质研究的批判性评估
A Critical Assessment of Research on Neurotransmitters in Alzheimer's Disease.
作者信息
Reddy P Hemachandra
机构信息
Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
出版信息
J Alzheimers Dis. 2017;57(4):969-974. doi: 10.3233/JAD-170256.
Abstract
The purpose of this mini-forum, "Neurotransmitters and Alzheimer's Disease", is to critically assess the current status of neurotransmitters in Alzheimer's disease. Neurotransmitters are essential neurochemicals that maintain synaptic and cognitive functions in mammals, including humans, by sending signals across pre- to post-synaptic neurons. Authorities in the fields of synapses and neurotransmitters of Alzheimer's disease summarize the current status of basic biology of synapses and neurotransmitters, and also update the current status of clinical trials of neurotransmitters in Alzheimer's disease. This article discusses the prevalence, economic impact, and stages of Alzheimer's dementia in humans.
摘要
本次小型论坛“神经递质与阿尔茨海默病”的目的是批判性地评估神经递质在阿尔茨海默病中的现状。神经递质是重要的神经化学物质，通过在突触前神经元和突触后神经元之间传递信号，维持包括人类在内的哺乳动物的突触和认知功能。阿尔茨海默病突触和神经递质领域的权威人士总结了突触和神经递质基础生物学的现状，同时也更新了神经递质在阿尔茨海默病临床试验的现状。本文讨论了人类阿尔茨海默病痴呆症的患病率、经济影响和阶段。
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