Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Milan, Italy,
Instituto de Fisica E. Gaviola, CONICET, Argentina, and Laboratory for Research and Instrumentation in Physics Applied to Medicine and X-Ray Imaging (LIIFAMIRx), National University of Cordoba, Cordoba, Argentina.
Front Biosci (Landmark Ed). 2017 Jun 1;22(10):1750-1759. doi: 10.2741/4569.
The concept of targeted radionuclide therapy (TRT) relies on the use of injected nuclear medicine as treating agents, targeted at the cellular or molecular level. The growth of the interest in TRT was stimulated by the advances in radionuclide production and labeling as well as by the improvement in the knowledge of appropriate and specific molecular targets. In recent years, different studies on TRT were focused on the evaluation of radionuclide compounds able to combine imaging of the disease with TRT, in a theranostic approach. This approach is of particular interest towards the personalization of treatments, allowing both the baseline characterization of oncological pathologies and treatment optimization by correct dosimetric calculation as well as therapy monitoring. This paper presents a review of recent literature on TRT, with a particular focus on clinical applications promoting such a theranostic approach, showing the impact of the synergy of diagnostic imaging and therapeutics.
靶向放射性核素治疗 (TRT) 的概念依赖于将注入的核医学作为治疗剂，靶向于细胞或分子水平。放射性核素生产和标记方面的进展以及对适当和特定分子靶标的知识的提高，激发了对 TRT 的兴趣增长。近年来，关于 TRT 的不同研究集中在评估能够将疾病的成像与 TRT 相结合的放射性核素化合物上，采用一种治疗诊断方法。这种方法对于治疗的个性化特别有意义，允许通过正确的剂量计算以及治疗监测来对肿瘤病理学进行基线特征描述和治疗优化。本文对 TRT 的最新文献进行了综述，特别关注促进这种治疗诊断方法的临床应用，展示了诊断成像和治疗的协同作用的影响。
