Moghimi Mansour, Sobhan Mohammad Reza, Jarahzadeh Mohammad Hossein, Morovati-Sharifabad Majid, Aghili Kazem, Ahrar Hossein, Zare-Shehneh Masoud, Neamatzadeh Hossein
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Email:
Asian Pac J Cancer Prev. 2019 Mar 26;20(3):675-682. doi: 10.31557/APJCP.2019.20.3.675.
Background: Some studies have investigated the association of GSTM1, GSTT1, GSTM3, and GSTP1 polymorphisms with susceptibility to osteosarcoma; however, these studies results are inconsistent and inconclusive. In order to drive a more precise estimation, the present case-control study and meta-analysis was performed to investigate association of GSTM1, GSTT1, GSTM3, and GSTP1 polymorphisms with osteosarcoma. Methods: Eligible articles were identified by a search of several electronic databases for the period up to May 5, 2018. Odds ratios were pooled using either fixed-effects or random effects models. Results: Finally, a total of 24 case-control studies with 2,405 osteosarcoma cases and 3,293 controls were included in the present meta-analysis. Overall, significantly increased osteosarcoma risk was found when all studies were pooled into the meta-analysis of GSTT1 (Null vs. Present: OR= 1.247 95% CI 1.020-1.524, P= 0.031) and GSTP1 polymorphism (B vs. A: OR= 8.899 95% CI 2.722-29.094, P≤0.001). In the stratified, significantly increased osteosarcoma risk was observed for GSTT1 polymorphism among Asians (Null vs. Present: OR= 1.300 95% CI 1.034-1.635, P= 0.025), but not among Caucasians. Conclusions: This meta-analysis demonstrated that GSTP1 and GSTT1 null genotype are associated with the risk of osteosarcoma. Future large welldesigned epidemiological studies are warranted to validate our results.
一些研究调查了谷胱甘肽S-转移酶M1（GSTM1）、谷胱甘肽S-转移酶T1（GSTT1）、谷胱甘肽S-转移酶M3（GSTM3）和谷胱甘肽S-转移酶P1（GSTP1）基因多态性与骨肉瘤易感性的关系；然而，这些研究结果并不一致且尚无定论。为了进行更精确的评估，本病例对照研究和荟萃分析旨在探讨GSTM1、GSTT1、GSTM3和GSTP1基因多态性与骨肉瘤的关联。方法：通过检索多个电子数据库，确定截至2018年5月5日的符合条件的文章。使用固定效应或随机效应模型汇总比值比。结果：最终，本荟萃分析纳入了24项病例对照研究，共2405例骨肉瘤病例和3293例对照。总体而言，当所有研究纳入GSTT1荟萃分析（无效基因型与存在基因型：比值比=1.247，95%置信区间1.020 - 1.524，P = 0.031）和GSTP1基因多态性分析（B型与A型：比值比=8.899，95%置信区间2.722 - 29.094，P≤0.001）时，发现骨肉瘤风险显著增加。在分层分析中，亚洲人GSTT1基因多态性的骨肉瘤风险显著增加（无效基因型与存在基因型：比值比=1.300，95%置信区间1.034 - 1.635，P = 0.025），而高加索人则未观察到这种情况。结论：本荟萃分析表明，GSTP1和GSTT1无效基因型与骨肉瘤风险相关。未来需要进行大规模设计良好的流行病学研究来验证我们的结果。
