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一名难治性癫痫患者孕期成功植入并即刻激活迷走神经刺激器(VNS):病例说明及文献综述

Successful implantation and immediate activation of Vagus Nerve Stimulation (VNS) during pregnancy in a patient with intractable epilepsy: A case illustration and review of the literature.

作者信息

Jazebi N, Moghimi N, Lall R, Osadebey E, Ortega-Barnett J, Masel T

机构信息

Department of Neurology, University of Texas Medical Branch, Galveston, TX, United States.

Department of Neurology, University of Texas Medical Branch, Galveston, TX, United States.

出版信息

J Clin Neurosci. 2017 Aug;42:114-115. doi: 10.1016/j.jocn.2017.03.044. Epub 2017 Apr 12.

DOI:10.1016/j.jocn.2017.03.044
PMID:28410885
Abstract

While Vagus Nerve Stimulation (VNS) is proven to be a safe and effective adjunctive therapy in the general population with medically intractable seizures, little is published about its implantation during pregnancy. Here we illustrate the case of a 21year old primigravid woman with medically refractory seizures who underwent safe and successful VNS implantation and immediate activation of the device in her 32nd week of pregnancy, resulting in dramatically improved seizure control and subsequent delivery of a healthy baby.

摘要

虽然迷走神经刺激术(VNS)已被证明是治疗药物难治性癫痫的普通人群中的一种安全有效的辅助疗法,但关于其在孕期植入的报道却很少。在此,我们阐述了一名21岁初孕妇的病例,该孕妇患有药物难治性癫痫,在其怀孕第32周时接受了安全且成功的VNS植入及装置即刻激活,结果癫痫控制得到显著改善,并随后分娩出一名健康婴儿。

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Successful implantation and immediate activation of Vagus Nerve Stimulation (VNS) during pregnancy in a patient with intractable epilepsy: A case illustration and review of the literature.一名难治性癫痫患者孕期成功植入并即刻激活迷走神经刺激器(VNS):病例说明及文献综述
J Clin Neurosci. 2017 Aug;42:114-115. doi: 10.1016/j.jocn.2017.03.044. Epub 2017 Apr 12.
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[Vagus nerve stimulation for intractable epilepsy: A retrospective bicentric cohort study of 101 patients operated on between 1999 and 2010].[迷走神经刺激术治疗难治性癫痫:一项对1999年至2010年间接受手术的101例患者的回顾性双中心队列研究]
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Refractory epilepsy in tuberous sclerosis: vagus nerve stimulation with or without subsequent resective surgery.结节性硬化症的耐药性癫痫:迷走神经刺激术联合或不联合后续切除术。
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Pregnancy Outcomes in Epilepsy Patients Treated with Neuromodulating Devices.接受神经调节设备治疗的癫痫患者的妊娠结局。
Curr Neurol Neurosci Rep. 2025 Jul 21;25(1):50. doi: 10.1007/s11910-025-01441-7.
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Invasive Neurostimulation During Pregnancy for Treatment of Epilepsy and Tourette Syndrome: Maternal and Fetal Outcomes.孕期侵入性神经刺激治疗癫痫和抽动秽语综合征:母婴结局
Neurol Clin Pract. 2025 Aug;15(4):e200498. doi: 10.1212/CPJ.0000000000200498. Epub 2025 Jun 11.
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Third generation antiseizure medications exposure during pregnancy and neonatal adverse birth outcomes: A systematic review.
孕期第三代抗癫痫药物暴露与新生儿不良出生结局:系统评价。
Sci Prog. 2024 Apr-Jun;107(2):368504241234781. doi: 10.1177/00368504241234781.
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Safe and effective implantation and use of vagal nerve stimulation in new-onset refractory status epilepticus in early pregnancy: a case report.迷走神经刺激在孕早期新发难治性癫痫持续状态中的安全有效植入及应用:一例报告
Front Neurol. 2023 May 15;14:1183080. doi: 10.3389/fneur.2023.1183080. eCollection 2023.