Ohemeng Kwaku K, Parham Kourosh
Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, UCONN School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030-8083, USA.
Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, UCONN School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030-8083, USA.
Otolaryngol Clin North Am. 2020 Feb;53(1):127-143. doi: 10.1016/j.otc.2019.09.008. Epub 2019 Nov 1.
Vagal nerve stimulation (VNS) therapy is a surgical treatment that involves the implantation of a device to electrically stimulate the vagus nerve. It is indicated as an adjunctive treatment of epilepsy that is refractory to antiepileptic medications and for treatment-resistant depression. The exact mechanism by which VNS achieves its effects is not known, but various mechanisms have been proposed, including afferent vagal projections to seizure-generating regions of the brain and desynchronization of hypersynchronized cortical activity. The most common complications of VNS therapy include hoarseness, throat pain/dysphagia, coughing, and shortness of breath.
迷走神经刺激（VNS）疗法是一种外科治疗方法，涉及植入一种装置来对迷走神经进行电刺激。它被用作对抗癫痫药物难治的癫痫的辅助治疗以及用于治疗抵抗性抑郁症。VNS发挥其作用的确切机制尚不清楚，但已提出了多种机制，包括迷走神经向大脑癫痫发作产生区域的传入投射以及超同步皮层活动的去同步化。VNS疗法最常见的并发症包括声音嘶哑、咽痛/吞咽困难、咳嗽和呼吸急促。
