Sukumar Madhusudhanan, Kishton Rigel J, Restifo Nicholas P
Center for Cell-Based Therapy, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Center for Cell-Based Therapy, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Curr Opin Immunol. 2017 Jun;46:14-22. doi: 10.1016/j.coi.2017.03.011. Epub 2017 Apr 13.
Immunotherapies designed to trigger T cell destruction of tumor cells can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Evidence suggests that powering the T cell response - how T cells generate energy - plays an important role in their effectiveness. Furthermore the metabolism of T cells can be modulated to improve their anti-cancer activities. In this review, we will discuss the key metabolic properties of anti-cancer T cells, along with potential strategies to enhance immunotherapy through the modulation of T cell metabolism.
旨在触发T细胞对肿瘤细胞进行破坏的免疫疗法，可使那些对现有治疗方案耐药的癌症患者产生持续且完全的反应。有证据表明，驱动T细胞反应——即T细胞如何产生能量——在其有效性方面起着重要作用。此外，T细胞的代谢可以被调节，以提高其抗癌活性。在这篇综述中，我们将讨论抗癌T细胞的关键代谢特性，以及通过调节T细胞代谢来增强免疫疗法的潜在策略。
