Muema Jackson M, Bargul Joel L, Njeru Sospeter N, Onyango Joab O, Imbahale Susan S
Department of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000-00200, Nairobi, Kenya.
Molecular Biology and Bioinformatics Unit, International Centre of Insect Physiology and Ecology, P.O. Box 30772-00100, Nairobi, Kenya.
Parasit Vectors. 2017 Apr 17;10(1):184. doi: 10.1186/s13071-017-2122-8.
Malaria presents an overwhelming public health challenge, particularly in sub-Saharan Africa where vector favourable conditions and poverty prevail, potentiating the disease burden. Behavioural variability of malaria vectors poses a great challenge to existing vector control programmes with insecticide resistance already acquired to nearly all available chemical compounds. Thus, approaches incorporating plant-derived compounds to manipulate semiochemical-mediated behaviours through disruption of mosquito olfactory sensory system have considerably gained interests to interrupt malaria transmission cycle. The combination of push-pull methods and larval control have the potential to reduce malaria vector populations, thus minimising the risk of contracting malaria especially in resource-constrained communities where access to synthetic insecticides is a challenge. In this review, we have compiled information regarding the current status of knowledge on manipulation of larval ecology and chemical-mediated behaviour of adult mosquitoes with plant-derived compounds for controlling mosquito populations. Further, an update on the current advancements in technologies to improve longevity and efficiency of these compounds for field applications has been provided.
疟疾带来了巨大的公共卫生挑战，尤其是在撒哈拉以南非洲地区，那里有利于病媒滋生的条件和贫困状况普遍存在，加重了疾病负担。疟疾媒介的行为变异性对现有的病媒控制项目构成了巨大挑战，因为几乎所有可用的化学化合物都已产生了抗药性。因此，通过破坏蚊子嗅觉传感系统来利用植物源化合物操纵信息化学物质介导行为的方法，已在很大程度上引起了人们的兴趣，以阻断疟疾传播周期。推拉法与幼虫控制相结合，有可能减少疟疾媒介种群，从而将感染疟疾的风险降至最低，特别是在难以获取合成杀虫剂的资源匮乏社区。在本综述中，我们收集了有关利用植物源化合物操纵幼虫生态和成年蚊子化学介导行为以控制蚊子种群的现有知识状况的信息。此外，还提供了有关提高这些化合物在实地应用中的寿命和效率的当前技术进展的最新情况。
