针对猪繁殖与呼吸综合征病毒的体液免疫效应机制
Effector mechanisms of humoral immunity to porcine reproductive and respiratory syndrome virus.
作者信息
Rahe Michael C, Murtaugh Michael P
机构信息
Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN, 55108 USA.
Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN, 55108 USA.
出版信息
Vet Immunol Immunopathol. 2017 Apr;186:15-18. doi: 10.1016/j.vetimm.2017.02.002. Epub 2017 Feb 20.
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) continues to afflict swine nearly 30 years after it was first discovered as the causative agent of "mystery swine disease". Immunological tools of vaccination and exposure to virulent viruses have not succeeded in achieving control and prevention of PRRSV. Humoral immunity, mediated by antibodies, is a hallmark of anti-viral immunity, but little is known about the effector mechanisms of humoral immunity against PRRSV. It is essential to understand the immunological significance of antibody functions, including recently described broadly neutralizing antibodies and potential non-neutralizing activities, in the immune response to PRRSV. Here, we review recent research from PRRSV and other host-pathogen interactions to inform novel routes of exploration into PRRSV humoral immunity which may be important for identifying the immunological correlates of protection against PRRSV infection.
摘要
猪繁殖与呼吸综合征病毒（PRRSV）自首次被发现为“神秘猪病”的病原体近30年来，一直困扰着养猪业。疫苗接种和接触强毒病毒等免疫手段未能成功控制和预防PRRSV。由抗体介导的体液免疫是抗病毒免疫的一个标志，但对于针对PRRSV的体液免疫效应机制知之甚少。了解抗体功能在PRRSV免疫反应中的免疫学意义至关重要，这些功能包括最近描述的广泛中和抗体和潜在的非中和活性。在此，我们综述了PRRSV及其他宿主-病原体相互作用的最新研究，为探索PRRSV体液免疫的新途径提供信息，这对于确定预防PRRSV感染的免疫相关因素可能具有重要意义。
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