Liu-Smith Feng, Farhat Ahmed Majid, Arce Anthony, Ziogas Argyrios, Taylor Thomas, Wang Zi, Yourk Vandy, Liu Jing, Wu Jun, McEligot Archana J, Anton-Culver Hoda, Meyskens Frank L
Department of Epidemiology, University of California, Irvine, California; Department of Medicine, University of California, Irvine, California.
Department of Biomedical Engineering, University of California, Irvine, California.
J Am Acad Dermatol. 2017 Mar;76(3):499-505.e3. doi: 10.1016/j.jaad.2016.08.027. Epub 2016 Oct 26.
Cutaneous melanoma (CM) incidence rates continue to increase, and the reasons are unknown. Previously, we reported a unique age-specific sex difference in melanoma that suggested additional causes other than solar ultraviolet (UV) radiation.
This study attempted to understand whether and how UV radiation differentially impacts the CM incidence in men and women.
CM data and daily UV index (UVI) from 31 cancer registries were collected for association analysis. A second dataset from 42 US states was used for validation.
There was no association between log-transformed female CM rates and levels of UVI, but there was a significant association between male rates and UVI and a significant association between overall rates and UVI. The 5-year age-specific rate-UVI association levels (represented by Pearson's coefficient ρ) increased with age in men, but age-specific ρ levels remained low and unchanged in women. The significant rate-UVI association in men and nonassociation in women was validated in a population of white residents of the United States.
Confounders, including temperature and latitude, are difficult to separate from UVI.
Ambient UVI appears to be associated with melanoma incidence in males but not in females.
皮肤黑色素瘤（CM）的发病率持续上升，原因尚不清楚。此前，我们报道了黑色素瘤中一种独特的年龄特异性性别差异，这表明除太阳紫外线（UV）辐射外还有其他原因。
本研究试图了解紫外线辐射是否以及如何对男性和女性的CM发病率产生不同影响。
收集了31个癌症登记处的CM数据和每日紫外线指数（UVI）进行关联分析。来自美国42个州的第二个数据集用于验证。
经对数转换的女性CM发病率与UVI水平之间无关联，但男性发病率与UVI之间存在显著关联，总体发病率与UVI之间也存在显著关联。男性按年龄划分的5年发病率-UVI关联水平（以皮尔逊系数ρ表示）随年龄增长而增加，但女性按年龄划分的ρ水平保持较低且不变。在美国白人居民群体中验证了男性发病率与UVI之间的显著关联以及女性中无关联。
包括温度和纬度在内的混杂因素难以与UVI区分开来。
环境UVI似乎与男性黑色素瘤发病率相关，而与女性无关。
