Panarese Fabrizio, Gualdi Giulio, Di Nicola Marta, Giannini Cosimo, Polidori Nella, Giuliani Federica, Mohn Angelika, Amerio Paolo
Department of Dermatology, University "G D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
Department of Experimental and Clinical Sciences, Biostatistic Laboratory, University "G D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
J Clin Med. 2022 Jan 29;11(3):736. doi: 10.3390/jcm11030736.
Recent reports have confirmed higher levels of growth hormone (GH) receptor (GHR) transcripts in malignant melanomas (MM), yet the role of GH in the pathogenesis of MM remains controversial. Although melanocytes appear to be hormonally responsive, the effects of GH on MM cells are less clear. A direct correlation between GH administration and the development of melanoma seems possible. Our study aimed to assess whether GH supplementation in children with growth hormone deficiency (GHD) could induce changes in the melanocytic lesions both from a dimensional and dermoscopic point of view. The study population consisted of 14 patients sorted into two groups. The experimental group consisted of seven GHD pediatric patients who underwent dermatological examination with epiluminescence through the use of digital video recording of all melanocytic lesions before and after 12 months of GH supplementation, whilst the control group consisted of seven healthy pediatric patients matched for age, sex and phototype. All patients were evaluated according to auxological and dermatological features. A total of 225 melanocytic lesions were examined in the experimental group and 236 in the control group. Our study shows a significant increase in the mean size values of the lesions in the study group but not in the control group. Increases in the dermoscopic ABCD Score and in BMI correlated to an increase in the size of the melanocytic lesions and the dermoscopic parameters. The increase in SDS Height correlated with ABCD Score changes and with dermoscopic score structures. No differences were found compared to the control group. Dimensional/structural modifications in melanocytic lesions of patients treated with GH were closely related to weight and statural growth and can be considered a normal physiological process induced by GH supplementation.
最近的报告证实，恶性黑色素瘤（MM）中生长激素（GH）受体（GHR）转录本水平较高，但GH在MM发病机制中的作用仍存在争议。尽管黑素细胞似乎对激素有反应，但GH对MM细胞的影响尚不清楚。GH给药与黑色素瘤的发生之间似乎存在直接关联。我们的研究旨在评估生长激素缺乏症（GHD）儿童补充GH是否会从尺寸和皮肤镜角度引起黑素细胞病变的变化。研究人群包括14名患者，分为两组。实验组由7名GHD儿科患者组成，他们在补充GH 12个月前后通过数字视频记录对所有黑素细胞病变进行了皮肤镜检查，而对照组由7名年龄、性别和光型匹配的健康儿科患者组成。所有患者均根据生长发育和皮肤学特征进行评估。实验组共检查了225个黑素细胞病变，对照组检查了236个。我们的研究表明，研究组病变的平均大小值显著增加，而对照组没有。皮肤镜ABCD评分和BMI的增加与黑素细胞病变大小和皮肤镜参数的增加相关。SDS身高的增加与ABCD评分变化和皮肤镜评分结构相关。与对照组相比未发现差异。接受GH治疗的患者黑素细胞病变的尺寸/结构改变与体重和身高增长密切相关，可被视为补充GH引起的正常生理过程。
