用于基因递送和DNA疫苗接种的聚合物材料
Polymeric Materials for Gene Delivery and DNA Vaccination.
作者信息
Nguyen David N, Green Jordan J, Chan Juliana M, Longer Robert, Anderson Daniel G
机构信息
Massachusetts Institute of Technology, 77 Massachusetts Ave, E25 Room 342, Cambridge, MA 02139 (USA).
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave, E25 Room 342, Cambridge, MA 02139 (USA).
出版信息
Adv Mater. 2009 Feb 23;21(8):847-867. doi: 10.1002/adma.200801478. Epub 2008 Dec 4.
Abstract
Gene delivery holds great potential for the treatment of many different diseases. Vaccination with DNA holds particular promise, and may provide a solution to many technical challenges that hinder traditional vaccine systems including rapid development and production and induction of robust cell-mediated immune responses. However, few candidate DNA vaccines have progressed past preclinical development and none have been approved for human use. This Review focuses on the recent progress and challenges facing materials design for nonviral DNA vaccine drug delivery systems. In particular, we highlight work on new polymeric materials and their effects on protective immune activation, gene delivery, and current efforts to optimize polymeric delivery systems for DNA vaccination.
摘要
基因递送在许多不同疾病的治疗中具有巨大潜力。DNA疫苗接种具有特殊的前景，并且可能为许多阻碍传统疫苗系统的技术挑战提供解决方案，包括快速开发和生产以及诱导强大的细胞介导免疫反应。然而，很少有候选DNA疫苗进入临床前开发阶段，并且没有一种被批准用于人类。本综述重点关注非病毒DNA疫苗药物递送系统材料设计面临的最新进展和挑战。特别是，我们强调了新型聚合物材料的研究及其对保护性免疫激活、基因递送的影响，以及目前为优化DNA疫苗接种的聚合物递送系统所做的努力。
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