Khan Abidullah, Haider Iqbal, Ayub Maimoona, Khan Salman
Department of Medicine, Khyber Teaching Hospital, Peshawar, 25000, Pakistan.
F1000Res. 2017 Feb 10;6:126. doi: 10.12688/f1000research.10763.3. eCollection 2017.
Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study. On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Spearman's rho and Pearson's correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis. The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant ( <0.001). MPV had an inverse relationship with both ESR (r=-0.93, <0.001) and SLEDAI (r = -0.89, <0.001). However, there was a strong positive correlation between ESR and SLEDAI (r =0.90, <0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% ( < 0.001). Higher disease activity in SLE is associated with a correspondingly low MPV.
在用于监测系统性红斑狼疮（SLE）疾病活动的不同临床和实验室参数中，平均血小板体积（MPV）是一种新型生物标志物。尽管MPV已在类风湿关节炎等其他风湿性疾病中得到研究，但其在成人SLE中的作用仍有待明确，尤其是在巴基斯坦。本研究的目的是评估MPV作为SLE疾病活动生物标志物的作用。通过连续非概率抽样技术招募了50名患者进行这项横断面研究。根据他们的SLE疾病活动指数（SLEDAI）得分大于或小于5，这50名参与者分别被分为两个相等的组；25名活动性SLE患者，以及另外25名稳定、非活动性狼疮参与者。在每组中测量MPV，并使用SPSS 16版进行比较。MPV也与SLEDAI和红细胞沉降率（ESR）相关。应用独立样本t检验、Spearman秩相关检验和Pearson相关检验。通过ROC分析检查MPV的敏感性和特异性。活动性SLE患者（n = 25，均值[M]=7.12，标准差=1.01）的MPV在数值上低于非活动性SLE组（n = 25，M = 10.12，标准差=0.97），且具有统计学意义（<0.001）。MPV与ESR（r = -0.93，<0.001）和SLEDAI（r = -0.89，<0.001）均呈负相关。然而，ESR和SLEDAI之间存在强正相关（r = 0.90，<0.001）。对于MPV，截断值小于8.5fl时，敏感性为92%，特异性为100%（<0.001）。SLE中较高的疾病活动度与相应较低的MPV相关。
