Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Department of Internal Medicine, Faculty of Medicine, Medeniyet University, Istanbul, Turkey.
Int J Clin Pract. 2021 Nov;75(11):e14676. doi: 10.1111/ijcp.14676. Epub 2021 Aug 7.
Systemic lupus erythematosus (SLE) is a connective tissue disease that is chronic, recurrent and multisystem with unknown aetiology. There is still no single biomarker that is pathognomonic for the disease. We know that platelets are the main part of haemostasis and thrombosis. We aimed to investigate whether there is a connection between MPV with SLE and inflammatory markers.
We have included 39 female patients with SLE and 45 controls in this study. In both groups, erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP) levels and MPV levels were investigated. Clinical findings and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) were evaluated in patients.
There was no significant difference between the two groups in terms of demographic data. The MPV was 8.1 ± 0.5 (mean ± SD) in the patient's group and 7.6 ± 0.3 in the control group. There was a significant difference between the two groups in terms of MPV (P < .001). The ESR level was 30.7 ± 29 in the patient's group and 16.7 ± 10 in the control group. In the patient's group, the CRP levels were higher compared with that of the control group (8.2 ± 13, 4.5 ± 4, respectively). We found a statistically significant positive correlation between MPV with arthritis (r = .310,P = .004), nephritis (r = .446,P < .001), central nervous system involvement (r = .241,P = .027), vasculitis (r = .228,P = .037) and SLEDAI (r = .329,P = .002). In our study, we found increased levels of MPV in patients with SLE. Also, we observed a positive correlation among MPV with sedimentation, CRP, clinical manifestations and SLEDAI.
We consider that MPV may be a new activation indicator for the SLE.
系统性红斑狼疮（SLE）是一种慢性、复发性、多系统疾病，病因不明。目前还没有单一的生物标志物能明确诊断该病。我们知道血小板是止血和血栓形成的主要成分。我们旨在研究血小板平均体积（MPV）与 SLE 之间是否存在关联，以及与炎症标志物之间的关系。
本研究纳入了 39 名女性 SLE 患者和 45 名对照者。在两组中，均检测了红细胞沉降率（ESR）、血清 C 反应蛋白（CRP）水平和血小板平均体积（MPV）。评估了患者的临床发现和系统性红斑狼疮疾病活动指数（SLEDAI）。
两组在人口统计学数据方面无显著差异。患者组的 MPV 为 8.1±0.5（均值±标准差），对照组为 7.6±0.3。两组的 MPV 有显著差异（P<0.001）。患者组的 ESR 水平为 30.7±29，对照组为 16.7±10。在患者组中，CRP 水平高于对照组（8.2±13，4.5±4）。我们发现 MPV 与关节炎（r=0.310，P=0.004）、肾炎（r=0.446，P<0.001）、中枢神经系统受累（r=0.241，P=0.027）、血管炎（r=0.228，P=0.037）和 SLEDAI（r=0.329，P=0.002）之间存在显著正相关。在本研究中，我们发现 SLE 患者的 MPV 水平升高。此外，我们观察到 MPV 与沉降率、CRP、临床表现和 SLEDAI 之间存在正相关。
我们认为 MPV 可能是 SLE 的一个新的激活指标。
