Awadh Nabaa Ihsan, Gorial Faiq Isho, Hammadi Reem Abbas, Ibrahim Mariam K, Majeed Saba Hussein, Mohammed Maab Jasim
Rheumatology Unit, Department of Internal Medicine, Baghdad Teaching Hospital, Iraq.
Rheumatology Unit, Department of Internal Medicine, College of Medicine, University of Baghdad, Iraq.
Reumatologia. 2022;60(3):173-182. doi: 10.5114/reum.2022.117837. Epub 2022 Jul 13.
The mean platelet volume to lymphocyte ratio (MPVLR) and platelet distribution width to lymphocyte ratio (PDWLR) have the potential to serve as markers of inflammation which may indicate disease activity. The mean platelet volume to lymphocyte ratio and PDWLR were assessed in patients with systemic lupus erythematosus (SLE) in this study.
Sixty-two patients with systemic lupus erythematosus and 79 controls who were age and gender matched were included. Their sociodemographic information, as well as disease activity scores based on the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), disease duration, current medications, lymphocytes, platelets, platelet distribution width (PDW), and mean platelet volume (MPV), anti-nuclear antibody (ANA), anti-double stranded deoxyribonucleic acid (anti-dsDNA), and complement components (C3, C4) were recorded. The correlations of MPVLR and PDWLR with disease activity and some laboratory parameters were analyzed.
Lupus patients had significantly higher median (interquartile range) values for MPVLR and PDWLR than controls (5.69 [1.16-23.67] vs. 4.40 [2.78-11.93], = 0.009) and 10.51 (2.87-79.37) vs. 5.21 (2.88-14.66), < 0.001] respectively. According to the ROC curve, > 7.53 was the best PDWLR cut-off value for predicting SLE with a sensitivity of 71%, a specificity of 87% and an accuracy of 82.6%, whereas the optimum MPVLR cut-off value was > 6.46 with a sensitivity of 45.2%, a specificity of 88.9% and an accuracy of 76.8%. In addition, MPVLR had a significant positive correlation with SLEDAI ( = 0.34, = 0.008). However, there was no significant correlation between PDWLR and SLEDAI ( = 0.23, = 0.067). Furthermore, PDWLR had a significant positive correlation with PDW ( = 0.482, < 0.001), while MPVLR had a significant negative correlation with C3 level ( = -0.260, = 0.042). Both PDWLR and MPVLR were positively correlated with nephritis ( = 0.388, = 0.002; = 0.246, = 0.038, respectively).
The platelet distribution width to lymphocyte ratio can be considered as an assisting biomarker in the diagnosis of SLE with the other clinical and serological parameters. The mean platelet volume to lymphocyte ratio may be used in the evaluation of disease activity in SLE patients.
平均血小板体积与淋巴细胞比值（MPVLR）和血小板分布宽度与淋巴细胞比值（PDWLR）有可能作为炎症标志物，提示疾病活动情况。本研究对系统性红斑狼疮（SLE）患者的MPVLR和PDWLR进行了评估。
纳入62例系统性红斑狼疮患者和79例年龄及性别匹配的对照。记录他们的社会人口统计学信息，以及基于系统性红斑狼疮疾病活动指数（SLEDAI）的疾病活动评分、病程、当前用药情况、淋巴细胞、血小板、血小板分布宽度（PDW）、平均血小板体积（MPV）、抗核抗体（ANA）、抗双链脱氧核糖核酸（抗dsDNA）和补体成分（C3、C4）。分析MPVLR和PDWLR与疾病活动及一些实验室参数的相关性。
狼疮患者的MPVLR和PDWLR中位数（四分位间距）显著高于对照组（分别为5.69[1.16 - 23.67]对4.40[2.78 - 11.93]，P = 0.009）和10.51（2.87 - 79.37）对5.21（2.88 - 14.66），P < 0.001]。根据ROC曲线，> 7.53是预测SLE的最佳PDWLR临界值，灵敏度为71%，特异性为87%，准确率为82.6%，而最佳MPVLR临界值> 6.46，灵敏度为45.2%，特异性为88.9%，准确率为76.8%。此外，MPVLR与SLEDAI呈显著正相关（r = 0.34，P = 0.008）。然而，PDWLR与SLEDAI之间无显著相关性（r = 0.23，P = 0.067）。此外，PDWLR与PDW呈显著正相关（r = 0.482，P < 0.001），而MPVLR与C3水平呈显著负相关（r = -0.260，P = 0.042）。PDWLR和MPVLR均与肾炎呈正相关（分别为r = 0.388，P = 0.002；r = 0.246，P = 0.038）。
血小板分布宽度与淋巴细胞比值可与其他临床和血清学参数一起作为SLE诊断的辅助生物标志物。平均血小板体积与淋巴细胞比值可用于评估SLE患者的疾病活动情况。
