Hong Xun Jie Jeesmond, Shinoj Vengalathunadakal K, Murukeshan Vadakke Matham, Baskaran Mani, Aung Tin
Nanyang Technological University, Centre for Optical and Laser Engineering, School of Mechanical and Aerospace Engineering, Singapore.
Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
J Med Imaging (Bellingham). 2017 Apr;4(2):026001. doi: 10.1117/1.JMI.4.2.026001. Epub 2017 Apr 10.
A flexible handheld imaging probe consisting of a [Formula: see text] charge-coupled device camera, light-emitting diode light sources, and near-infrared laser source is designed and developed. The imaging probe is designed with specifications to capture the iridocorneal angle images and posterior segment images. Light propagation from the anterior chamber of the eye to the exterior is considered analytically using Snell's law. Imaging of the iridocorneal angle region and fundus is performed on porcine samples and subsequently on small laboratory animals, such as the New Zealand white rabbit and nonhuman primate, . The integrated flexible handheld probe demonstrates high repeatability in iridocorneal angle and fundus documentation. The proposed concept and methodology are expected to find potential application in the diagnosis, prognosis, and management of glaucoma.
设计并开发了一种灵活的手持式成像探头，其由一个[公式：见文本]电荷耦合器件相机、发光二极管光源和近红外激光源组成。该成像探头的设计规格为可捕获虹膜角膜角图像和眼后节图像。利用斯涅尔定律对从眼睛前房到外部的光传播进行了分析。在猪样本上，随后又在小型实验动物（如新西兰白兔和非人灵长类动物）上进行了虹膜角膜角区域和眼底的成像。集成的灵活手持式探头在虹膜角膜角和眼底记录方面显示出高重复性。所提出的概念和方法有望在青光眼的诊断、预后和管理中找到潜在应用。
