Montpellier SupAgro, UMR 1208 IATE , Montpellier F-34060, France.
CIRAD, UMR 1208 IATE , Montpellier F-34060, France.
J Agric Food Chem. 2017 May 10;65(18):3591-3601. doi: 10.1021/acs.jafc.7b01054. Epub 2017 Apr 26.
The green chemistry era has pushed the scientific community to investigate and implement new solvents in phenolic compounds (PC) extraction as alternatives to organic solvents, which are toxic and may be dangerous. Recently, deep eutectic solvents (DES) have been applied as extraction solvents for PC. They have the advantages of biodegradability and ease of handling with very low toxicity. Nevertheless, the extraction process is affected by several factors: affinity between DES and the target compounds, the water content, the mole ratio between DES' starting molecules, the liquid/solid ratio between the DES and sample, and the conditions and extraction method. On the other hand, PC recovery from DES is a challenge because they can establish a strong hydrogen bond network. Alternatively, another possibility is to use DES as solvent extraction as well as formulation medium. In this way, DES can be suitable for cosmetics, pharmaceutical, or food applications.
绿色化学时代促使科学界研究并采用新的溶剂来替代有毒且可能危险的有机溶剂，从酚类化合物（PC）中萃取物质。最近，深共晶溶剂（DES）已被应用于 PC 的萃取溶剂。它们具有生物降解性和易于处理的优点，毒性非常低。然而，萃取过程受到多种因素的影响：DES 与目标化合物之间的亲和力、含水量、DES 起始分子的摩尔比、DES 和样品之间的液/固比以及条件和萃取方法。另一方面，从 DES 中回收 PC 是一个挑战，因为它们可以建立一个强大的氢键网络。另一种可能性是将 DES 既用作溶剂萃取，也用作制剂介质。这样，DES 就可以适用于化妆品、制药或食品应用。
