Riéffel Roberta Cougo, Agostini Lucas, Rodrigues Naira Poener, Berlitz Simone Jacobus, Marczak Lígia Damasceno Ferreira, Külkamp-Guerreiro Irene Clemes
Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil.
Programa de Pós-graduação em Engenharia Química, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil.
Pharmaceutics. 2025 Jul 25;17(8):962. doi: 10.3390/pharmaceutics17080962.
: Olive pomace, a byproduct of olive oil production, represents approximately 85% of the processed material and poses environmental risks when improperly discarded. Its composition is rich in polyphenols with potential for cosmetic use, especially in skin barrier care. : To develop a natural extract rich in antioxidants from olive pomace using sustainable solvents (water and 1,3-propanediol) for skin barrier support. : The phenolic composition and in vitro biological activities of the extracts were analyzed. : The extracts demonstrated a reducing capacity (15 to 33 mg GAE/g) and flavonoid content (4 to 5 mg QE/g). In addition, their antioxidant capacity was proven through the inhibition of the DPPH radical (7% to 91%) and ABTS (7% to 95%) and the reduction in oxidation in the beta-carotene/linoleic acid system (6% to 35%), presenting results superior to those of tocopherol acetate. The hydroxytyrosol and oleuropein compounds, ranging from 28 to 54 and 51 to 85 µg/mL, respectively, were quantified via HPLC. The extract with the highest levels of hydroxytyrosol and oleuropein was analyzed via UHPLC-QqTOF-MS, and 33 compounds were identified. This extract showed antiglycation activity (24% to 40%). The incorporation of this extract into a cosmetic emulsion resulted in sufficient antioxidant capacity to replace tocopherol acetate. : The use of effective extraction techniques and nontoxic solvents ensures the sustainability and safety of the extract for application as a natural cosmetic ingredient, aiming to promote the health and integrity of the skin barrier.
橄榄果渣是橄榄油生产的副产品，约占加工原料的85%，若处置不当会带来环境风险。其成分富含多酚，具有用于化妆品的潜力，尤其在皮肤屏障护理方面。：使用可持续溶剂（水和1,3 - 丙二醇）从橄榄果渣中开发富含抗氧化剂的天然提取物，以支持皮肤屏障。：分析了提取物的酚类成分和体外生物活性。：提取物表现出还原能力（15至33毫克没食子酸当量/克）和黄酮含量（4至5毫克槲皮素当量/克）。此外，通过抑制DPPH自由基（7%至91%）和ABTS（7%至95%）以及β - 胡萝卜素/亚油酸体系中氧化的减少（6%至35%）证明了它们的抗氧化能力，其结果优于醋酸生育酚。通过高效液相色谱法对羟基酪醇和橄榄苦苷化合物进行了定量，其含量分别为28至54微克/毫升和51至85微克/毫升。对羟基酪醇和橄榄苦苷含量最高的提取物通过超高效液相色谱 - 四极杆飞行时间质谱法进行了分析，鉴定出33种化合物。该提取物表现出抗糖化活性（24%至40%）。将该提取物加入化妆品乳液中可产生足够的抗氧化能力以替代醋酸生育酚。：使用有效的提取技术和无毒溶剂可确保提取物作为天然化妆品成分应用的可持续性和安全性，旨在促进皮肤屏障的健康和完整性。
