Rahman Ahmad Mukhlis Abdul, Bakar Amirul Ridzuan Abu, Yee Ang Qian, Zainudin Mohd Asraf Mohd, Daud Nik Muhammad Azhar Nik, Gunny Ahmad Anas Nagoor, Sarip Mohd Sharizan Md, Peron Ryan Vitthaya, Khairuddin Nurul Husna
Faculty of Chemical Engineering & Technology, Universiti Malaysia Perlis Jejawi Perlis 02600 Malaysia
M. Kandiah Faculty of Medicine and Health Sciences, University Tunku Abdul Rahman Bandar Sungai Long Kajang Selangor 43000 Malaysia.
RSC Adv. 2025 Feb 10;15(6):4296-4321. doi: 10.1039/d5ra00097a. eCollection 2025 Feb 6.
The present review attempts to evaluate the applicability of deep eutectic solvents (DES) as a green technique for the extraction of phytochemicals from L. and their therapeutic potential. Mango has been reported to show numerous therapeutic activities, which are attributed to its abundant source of bioactive compounds. Thus, the therapeutic potential of phytochemicals in mangoes is reviewed based on different reported bioactivity tests. The use of DESs is considered a green approach for the extraction of bioactive compounds from natural sources utilizing two or more components and a safe alternative for application in the nutritional, pharmaceutical and other sectors. The trends in the extraction of phytochemicals from mango using different DES components and different extraction parameters of the optimum protocol are reviewed. Hence, DESs are considered potential solvents with selective and efficient properties for extracting bioactive ingredients from mango. However, there are several knowledge gaps that need to be assessed for DES-based bioactive compound extraction from mango such as information on the local and specific varieties of mangoes, standardization of the extraction protocols and use of other parts of the mango plant as alternatives to its peel as bioactive sources. Accordingly, the extraction of bioactive compounds from mango using DESs will provide useful information for subsequent agricultural, pharmaceutical and nutraceutical applications in the future.
本综述旨在评估深共熔溶剂（DES）作为一种从芒果中提取植物化学物质的绿色技术的适用性及其治疗潜力。据报道，芒果具有多种治疗活性，这归因于其丰富的生物活性化合物来源。因此，基于不同报道的生物活性测试，对芒果中植物化学物质的治疗潜力进行了综述。使用DES被认为是一种利用两种或更多种成分从天然来源提取生物活性化合物的绿色方法，并且是在营养、制药和其他领域应用的安全替代品。综述了使用不同DES成分从芒果中提取植物化学物质的趋势以及最佳方案的不同提取参数。因此，DES被认为是具有选择性和高效特性的潜在溶剂，可用于从芒果中提取生物活性成分。然而，对于基于DES从芒果中提取生物活性化合物，仍有几个知识空白需要评估，例如关于芒果本地和特定品种信息、提取方案的标准化以及使用芒果植株其他部位替代其果皮作为生物活性来源。因此，使用DES从芒果中提取生物活性化合物将为未来后续的农业、制药和营养保健品应用提供有用信息。
