Kamari Younes, Ghiaci Payam, Ghiaci Mehran
Department of Chemistry, Isfahan University of Technology, Isfahan 8415683111, Iran.
Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:822-828. doi: 10.1016/j.msec.2017.02.115. Epub 2017 Feb 27.
This study was conducted in two main stages. In the first stage, drug-loaded montmorillonite nanocomposites were prepared by intercalation of insulin into the montmorillonite layers in acidic deionized (DI) water. In the second stage, to increase the release of insulin from the prepared nanocomposites they were coated with TiO, an inorganic porous coating, by using titanium (IV) butoxide, as precursor. The prepared nanocomposites were characterized by FT-IR, XRD, FE-SEM, BET, DLS and Zeta potential analysis. After investigating the release behaviour of the nanocomposites by UV-Vis absorbance technique, the results revealed that incorporation of porous TiO coating increased the drug entrapment noticeably, and decreased the amount of drug release, so that nanocomposites without and with TiO coating released the drug after 60min and 22h in pH7.4, respectively. These results could be used in converting the insulin utilization from injection to oral.
