Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México (UNAM), Circuito Exterior S/N, Coyoacán, Cd. Universitaria C.P.04510, Ciudad de México, Mexico.
Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Circuito Exterior S/N, Coyoacán, Cd. Universitaria C.P.04510, Ciudad de México, Mexico.
Colloids Surf B Biointerfaces. 2018 Jul 1;167:397-406. doi: 10.1016/j.colsurfb.2018.04.020. Epub 2018 Apr 9.
In this work, we prepared a novel composite based on hybrid gelatin carriers and montmorillonite clay (MMT) to analyze its viability as controlled drug delivery system. The objective of this research involves the characterization of composites formed by structured lipid-gelatin micro-particles (MP) and MMT clay. This analysis included the evaluation of the composite according to its rheological properties, morphology (SEM), particle size, XRD, FT-IR, and in vitro drug release. The effect of pH in the properties of the composite is evaluated. A novel raspberry-like or armor MP/MMT clay composite is reported, in which the pH has an important effect on the final structure of the composite for ad-hoc drug delivery systems. For pH values below the isoelectric point, we obtained defined morphologies with entrapment efficiencies up to 67%. The pH level controls the MP/MMT composite release mechanism, restringing drug release in the stomach-like environment. Intended for oral administration, these results evidence that the MP/MMT composite represents an attractive alternative for intestinal-colonic controlled drug delivery systems.
在这项工作中，我们制备了一种基于混合明胶载体和蒙脱石粘土（MMT）的新型复合材料，以分析其作为控释给药系统的可行性。本研究的目的是对由结构化脂质-明胶微球（MP）和 MMT 粘土形成的复合材料进行表征。这包括根据流变特性、形态（SEM）、粒径、XRD、FT-IR 和体外药物释放对复合材料进行评估。还评估了 pH 对复合材料性质的影响。报道了一种新型的覆盆子状或盔甲状 MP/MMT 粘土复合材料，其中 pH 对特定药物输送系统的复合最终结构有重要影响。对于低于等电点的 pH 值，我们获得了具有高达 67%包封效率的明确定义的形态。pH 值控制着 MP/MMT 复合材料的释放机制，限制了在胃样环境中的药物释放。对于口服给药，这些结果表明，MP/MMT 复合材料代表了一种用于肠-结肠控释药物输送系统的有吸引力的替代方案。
