禽白血病病毒诱导的B细胞淋巴瘤中活化的c-myc基因无错义突变。
Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas.
作者信息
Hahn M, Hayward W S
机构信息
Graduate Program in Molecular Biology, Sloan-Kettering Institute for Cancer Research, New York, New York.
出版信息
Mol Cell Biol. 1988 Jun;8(6):2659-63. doi: 10.1128/mcb.8.6.2659-2663.1988.
Abstract
We have determined the nucleotide sequences of two independent DNA clones which contained the activated c-myc genes from avian leukosis virus-induced B-cell lymphomas. Neither of these c-myc genes contained missense mutations. This strongly supports the notion that the c-myc proto-oncogene in avian leukosis virus-induced B-cell lymphomas can be oncogenically activated by altered expression of the gene without a change in the primary structure of the gene product.
摘要
我们已经确定了两个独立DNA克隆的核苷酸序列，这些克隆包含来自禽白血病病毒诱导的B细胞淋巴瘤的活化c-myc基因。这两个c-myc基因均未包含错义突变。这有力地支持了以下观点：在禽白血病病毒诱导的B细胞淋巴瘤中，c-myc原癌基因可通过基因表达改变而致癌激活，而基因产物的一级结构并无变化。
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