Rabbitts T H, Forster A, Hamlyn P, Baer R
Nature. 1984;309(5969):592-7. doi: 10.1038/309592a0.
Our previous studies of a translocated c-myc gene in the Raji Burkitt's lymphoma cell showed somatic mutations in exons 1 and 2. We have extended these observations to two other translocated c-myc genes and find a common occurrence of mutation in the noncoding exon 1. We also found that in Raji cells, unlike other Burkitt's lymphoma cell lines, the normal allele of the c-myc gene is transcribed as well as the translocated gene. These results support a model in which c-myc oncogene activation in Burkitt's lymphoma occurs by disruption of a normal transcriptional control mechanism in which the c-myc protein is itself involved.
我们之前对拉吉伯基特淋巴瘤细胞中易位的c-myc基因的研究显示，外显子1和2存在体细胞突变。我们将这些观察结果扩展到另外两个易位的c-myc基因，发现非编码外显子1中普遍存在突变。我们还发现，在拉吉细胞中，与其他伯基特淋巴瘤细胞系不同，c-myc基因的正常等位基因与易位基因一样会被转录。这些结果支持了一种模型，即伯基特淋巴瘤中c-myc癌基因的激活是通过破坏一种正常的转录控制机制发生的，而c-myc蛋白本身参与了这种机制。
