中国人群中内皮细胞蛋白C受体基因多态性与脓毒症风险
Endothelial protein C receptor polymorphisms and risk of sepsis in a Chinese population.
作者信息
Liang Yanbing, Huang Xia, Jiang Yujie, Qin Yueqiu, Peng Dingwei, Huang Yuqing, Li Jin, Sooranna Suren R, Pinhu Liao
机构信息
1 Affiliated Hospital of Youjiang Medical University, Baise, Guangxi, PR China.
2 Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, UK.
出版信息
J Int Med Res. 2017 Apr;45(2):504-513. doi: 10.1177/0300060516686496. Epub 2017 Feb 13.
Objective To examine the potential relationship of EPCR polymorphisms and the risk of sepsis in a Chinese population. Methods Snapshot SNP genotyping assays and DNA sequencing methods were used to detect polymorphisms of the EPCR gene, rs2069948C/T (2532C/T) and rs867186A/G (6936A/G), in 64 patients with sepsis and in 113 controls. Soluble EPCR (sEPCR) was measured by ELISA. Results There were significant differences in the allele and genotype frequencies of EPCR gene rs2069948C/T and allele frequencies of rs867186A/G between male and female patients and controls. Females carrying rs2069948 C/T genotype or T allele and males carrying rs867186 A allele were associated with a significantly increased risk of sepsis. Plasma sEPCR levels of sepsis patients were higher than controls and showed no correlation with EPCR gene polymorphisms. Conclusions EPCR polymorphisms may be associated with increased risk of sepsis, but this has no effect on the release of sEPCR in patients with sepsis.
目的 探讨中国人群中EPCR基因多态性与脓毒症风险之间的潜在关系。方法 采用单核苷酸多态性（SNP）分型检测法和DNA测序法，对64例脓毒症患者和113例对照者进行EPCR基因rs2069948C/T（2532C/T）和rs867186A/G（6936A/G）多态性检测。采用酶联免疫吸附测定（ELISA）法检测可溶性EPCR（sEPCR）水平。结果 脓毒症患者与对照者在EPCR基因rs2069948C/T的等位基因和基因型频率以及rs867186A/G的等位基因频率上，男性和女性之间存在显著差异。携带rs2069948 C/T基因型或T等位基因的女性以及携带rs867186 A等位基因的男性脓毒症风险显著增加。脓毒症患者血浆sEPCR水平高于对照者，且与EPCR基因多态性无相关性。结论 EPCR基因多态性可能与脓毒症风险增加有关，但对脓毒症患者sEPCR的释放无影响。
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