对一个逃避X染色体失活的人类X连锁基因的甲基化分析。
Analysis of methylation of a human X located gene which escapes X inactivation.
作者信息
Mondello C, Goodfellow P J, Goodfellow P N
机构信息
Istituto di Genetica Biochimica ed Evoluzionistica del CNR, Pavia, Italy.
出版信息
Nucleic Acids Res. 1988 Jul 25;16(14B):6813-24. doi: 10.1093/nar/16.14.6813.
The gene MIC2 is located in the pseudoautosomal region at the ends of the short arms of the X and Y chromosomes. In females MIC2 escapes X inactivation. We have analyzed the methylation pattern of MIC2 on the active X, the inactive X chromosomes, and the Y chromosome. The 5' end of the gene contains a GC rich region which is unmethylated on the active X, the inactive X and on the Y. The body of the gene is characterized by variable methylation.
基因MIC2位于X和Y染色体短臂末端的拟常染色体区域。在女性中，MIC2逃避X染色体失活。我们分析了MIC2在活性X染色体、失活X染色体和Y染色体上的甲基化模式。该基因的5'端包含一个富含GC的区域，在活性X染色体、失活X染色体和Y染色体上均未甲基化。该基因的主体表现出可变甲基化。
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