细胞表面抗原基因座MIC2X逃避X染色体失活。
The cell surface antigen locus, MIC2X, escapes X-inactivation.
作者信息
Goodfellow P, Pym B, Mohandas T, Shapiro L J
出版信息
Am J Hum Genet. 1984 Jul;36(4):777-82.
Abstract
Recently, it was shown that the cell surface antigen defined by the monoclonal antibody 12E7 is expressed by both the human X and Y chromosomes; the gene loci on the X and Y chromosomes are referred to as MIC2X and MIC2Y, respectively. It was also shown that MIC2X is located in the region Xp22.3----Xpter and MIC2Y is in the region Ypter-Yq1.1. Here, we show that MIC2X escapes X-inactivation on structurally normal and abnormal inactive human X chromosomes.
摘要
最近研究表明，单克隆抗体12E7所定义的细胞表面抗原在人类X和Y染色体上均有表达；X和Y染色体上的基因座分别称为MIC2X和MIC2Y。研究还表明，MIC2X位于Xp22.3----Xpter区域，MIC2Y位于Ypter-Yq1.1区域。在此，我们表明MIC2X在结构正常和异常的失活人类X染色体上均逃避X染色体失活。
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本文引用的文献
1
KARYOTYPE-PHENOTYPE CORRELATIONS IN GONADAL DYSGENESIS AND THEIR BEARING ON THE PATHOGENESIS OF MALFORMATIONS.性腺发育不全中的核型-表型相关性及其对畸形发病机制的影响
J Med Genet. 1965 Jun;2(2):142-55. doi: 10.1136/jmg.2.2.142.
2
A human quantitative polymorphism related to Xg blood groups.一种与Xg血型相关的人类数量多态性。
Nature. 1981 Jan 29;289(5796):404-5. doi: 10.1038/289404a0.
3
Fertile females produced by inactivation of an X chromosome of "sex-reversed' mice.
Nature. 1982 Dec 2;300(5891):446-8. doi: 10.1038/300446a0.
4
Genetic homology and crossing over in the X and Y chromosomes of Mammals.哺乳动物X和Y染色体中的基因同源性与交叉互换
Hum Genet. 1982;61(2):85-90. doi: 10.1007/BF00274192.
5
Sequences on the human Y chromosome homologous to the autosomal gene for argininosuccinate synthetase.人类Y染色体上与精氨琥珀酸合成酶常染色体基因同源的序列。
Nature. 1982 Aug 12;298(5875):682-4. doi: 10.1038/298682a0.
6
Sex reversal in the mouse (Mus musculus) is caused by a recurrent nonreciprocal crossover involving the x and an aberrant y chromosome.小鼠（小家鼠）的性反转是由涉及X染色体和一条异常Y染色体的反复发生的非相互交叉所引起的。
Cell. 1982 Feb;28(2):205-16. doi: 10.1016/0092-8674(82)90338-5.
7
A human X-linked antigen defined by a monoclonal antibody.一种由单克隆抗体所定义的人类X连锁抗原。
Somatic Cell Genet. 1980 Nov;6(6):777-87. doi: 10.1007/BF01538976.
8
Male, female and intersex development in mice of identical chromosome constitution.
Nature. 1982 Dec 2;300(5891):445-6. doi: 10.1038/300445a0.
9
Differential expression of steroid sulphatase locus on active and inactive human X chromosome.类固醇硫酸酯酶基因座在人类活性和失活X染色体上的差异表达。
Nature. 1982 Oct 28;299(5886):838-40. doi: 10.1038/299838a0.
10
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Hum Genet. 1981;57(4):354-6. doi: 10.1007/BF00281683.
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