用阿霉素、长春新碱和强的松治疗成人急性淋巴细胞白血病。

Treatment of adult acute lymphoblastic leukemia with adriamycin, vincristine, and prednisone.

作者信息

Aviles A, Sinco A, Rivera R, Ambriz R, Herrera J G, Pizzuto J

出版信息

Med Pediatr Oncol. 1983;11(2):141-5. doi: 10.1002/mpo.2950110214.

Abstract

At the present time, it is possible to achieve up to a 95% complete remission in childhood acute lymphoblastic leukemia, using the combination of vincristine and prednisone. Nevertheless, it has not been possible to reproduce these results in the adult. For this reason, a third drug, in this case adriamycin in a low dose, was added to the vincristine-prednisone combination in the treatment of adult acute lymphoblastic leukemia (ALL). Complete remission was achieved in 45 of the 50 patients (90%). The median duration of remission was 23 months and the median survival time in this group was 31 months. The complications were minimal and the tolerance was good. From the point of view of our results and others reported in the literature, we consider that the combination of vincristine, prednisone, and adriamycin is a useful method for induction of remission of adult ALL.

摘要

目前，使用长春新碱和泼尼松联合治疗儿童急性淋巴细胞白血病，完全缓解率可达95%。然而，在成人中尚未能重现这些结果。因此，在治疗成人急性淋巴细胞白血病（ALL）时，在长春新碱-泼尼松联合方案中加入了第三种药物，即低剂量阿霉素。50例患者中有45例（90%）实现了完全缓解。缓解期的中位数为23个月，该组患者的中位生存时间为31个月。并发症极少，耐受性良好。从我们的结果以及文献中报道的其他结果来看，我们认为长春新碱、泼尼松和阿霉素联合是诱导成人ALL缓解的一种有效方法。