铁离子与毒素JSTX（一种存在于棒络新妇蛛（络新妇蜘蛛）毒腺中的谷氨酸受体阻断剂）反应时的显色情况。

Color development upon reaction of ferric ion with the toxin JSTX, a glutamate receptor blocker present in the venom gland of the spider Nephila clavata (Joro spider).

作者信息

Yoshioka M, Narai N, Pan-Hou H, Shimazaki K, Miwa A, Kawai N

机构信息

Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.

出版信息

Toxicon. 1988;26(4):414-6. doi: 10.1016/0041-0101(88)90011-6.

DOI:10.1016/0041-0101(88)90011-6

PMID:2841774

Abstract

A spider toxin, JSTX, derived from Nephila clavata, which blocks glutamate receptor was found to react with Fe3+. Mechanism of the coloration may be chelate formation since the green color completely faded upon the addition of EDTA. The colored JSTX significantly lost its neurophysiological activity. This unique coloration may be useful for not only detecting specific blockers of the glutamate receptor in spider venom but also for characterizing the glutamate receptor.

摘要

一种源自棒络新妇蛛（Nephila clavata）的蜘蛛毒素JSTX，它能阻断谷氨酸受体，被发现可与Fe3+发生反应。这种显色机制可能是形成了螯合物，因为加入乙二胺四乙酸（EDTA）后绿色完全褪去。显色后的JSTX显著丧失了其神经生理活性。这种独特的显色不仅可能有助于检测蜘蛛毒液中谷氨酸受体的特异性阻断剂，还可用于对谷氨酸受体进行表征。