蜘蛛毒素（JSTX）阻断海马锥体神经元中的谷氨酸突触。
Spider toxin (JSTX) blocks glutamate synapse in hippocampal pyramidal neurons.
作者信息
Saito M, Kawai N, Miwa A, Pan-Hou H, Yoshioka M
出版信息
Brain Res. 1985 Nov 4;346(2):397-9. doi: 10.1016/0006-8993(85)90878-9.
Effects of spider toxin (JSTX)--a specific blocker of glutamate receptors--on single pyramidal neurons of the hippocampus were studied using tissue slices in vitro. JSTX blocked the synaptic response in CA1 pyramidal cells evoked by Schaffer collateral stimulation without affecting the antidromic spike potential. The toxin suppressed glutamate-induced cell firings whereas it had little effect on aspartate-induced responses. The results suggest that glutamate is a neurotransmitter of the Schaffer collateral input to CA1 pyramidal neurons.
利用体外组织切片研究了蜘蛛毒素（JSTX）——一种谷氨酸受体的特异性阻断剂——对海马单个锥体神经元的作用。JSTX阻断了由Schaffer侧支刺激诱发的CA1锥体细胞的突触反应，而不影响逆向动作电位。该毒素抑制谷氨酸诱导的细胞放电，而对天冬氨酸诱导的反应影响很小。结果表明，谷氨酸是Schaffer侧支输入到CA1锥体神经元的神经递质。
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