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血浆干扰素-γ诱导蛋白10水平与围产期HIV感染中记忆B细胞表型异常相关。

Plasma Interferon-Gamma-Inducible Protein 10 Level Associates With Abnormal Memory B Cells Phenotypes in Perinatal HIV Infection.

作者信息

Contreras German A, Murphy James R, Heresi Gloria P

机构信息

From the *Division of Pediatric Infectious Diseases, Department of Pediatrics, McGovern Medical School, UT Health, Houston, Texas; and †Molecular Genetics and Antimicrobial Resistance Unit, Bosque University, Bogotá, Colombia.

出版信息

Pediatr Infect Dis J. 2017 Sep;36(9):e219-e222. doi: 10.1097/INF.0000000000001612.

DOI:10.1097/INF.0000000000001612
PMID:28419006
Abstract

We demonstrate for perinatally HIV-infected children and adolescents receiving combined antiretroviral therapy and in good clinical status with respect to HIV disease that high concentrations of interferon-gamma-inducible protein 10 associate with increased exhausted memory B cells.

摘要

我们证明,对于接受联合抗逆转录病毒治疗且HIV疾病临床状态良好的围产期感染HIV的儿童和青少年,高浓度的γ-干扰素诱导蛋白10与耗尽的记忆B细胞增加有关。

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